Synthesis of Multi‐substituted Benzamide Derivatives under Microwave Irradiation Conditions

Abstract

A facile microwave-assisted synthesis of N-[(Z)-1-(substituted carbamoyl)-2-arylvinyl] benzamide derivatives is accomplished via reactions of 4-arylmethylene-2-phenyloxazol-5(4H)-ones with different amines (for example methylamine, cyclopropylamine, para-toluidine, phenylamine) in ethylene glycol. This protocol broadens the scope of the reaction for the synthesis of N-benzamide derivatives.