Synthesis of Multifunctional Eu(III) Complex Doped Fe3O4/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging

Abstract

In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH2, the FOASET NC exhibits a small size of 60–70 nm and strong, sharp emission at λmax = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42–46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT). The heating efficiency was improved in the dual magnetic-photothermal heating mode.

Gold and Iron Oxide Nanoparticle Assemblies on Turnip Yellow Mosaic Virus for In-Solution Photothermal Experiments

“…Photothermal experiments were conducted using a laser irradiation (LD808E3WG13, Lasermate group, Inc., Walnut, CA, USA) at a wavelength of 808 nm with a varying power density (from 0.165 to 1.5 W/cm 2 ). For each experiment, a volume of 200 µL of the freshly prepared aqueous colloids of free IONPs and AuNPs, on one hand, and of their TYMV-based hybrids, on the other hand, was considered [ 44 ].…”

Electrospun Magnetic Nanofiber Mats for Magnetic Hyperthermia in Cancer Treatment Applications—Technology, Mechanism, and Materials

“…Research has found that magnetic hyperthermia is a novel procedure that offers a safe, powerful, and simple treatment method to meet these complicated challenges [92][93][94][95][96]. In this procedure, which has recently seen rapid development, magnetic nanomaterials can be used to improve hyperthermia efficiency compared to traditional hyperthermia methods for the erosion of tumors [97][98][99][100][101][102][103][104][105][106]. The most significant aspect of magnetic hyperthermia is that magnetic nanomaterials are distributed over very small areas so that the temperature behavior of healthy cells is not affected [107][108][109].…”

Multiwalled Carbon Nanotubes Decorated with Mn0.5Zn0.5Fe2O4 Nanoparticles for Magneto-Photothermal Cancer Therapy

“…Moreover, the photothermal therapy has long been limited to superficial tumors; in the best scenario, near-infrared light in the second region can penetrate breast tissue for 10 cm and skull/brain tissue or deep muscle for 4 cm. However, due to tissue absorption and light scattering, the photothermal effect is markedly weakened for the case of deep tumors. − Therefore, there have been initiatives to search for more effective hyperthermia therapy approach by consolidating different modulates. − An effective strategy involves the synergistic combination of magnetic hyperthermia (MHT) and photothermal therapy (PTT) to generate cumulative heating at a specific site of interest. In addition to the cumulative effect, this combined approach leverages the complementarity of PTT and MHT, leading to a synergistic hyperthermia effect.…”