2021
DOI: 10.2174/1573406416666201120103913
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Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc

Abstract: Aims: In search of new promising anti-cancer agents. Background: Six N-acyl derivatives of aminocombretastatin A-4 have been synthesized and evaluated as regards their interaction with tubulin and as c-Myc downregulators. Objective: This study is focused on the synthesis and the biological evaluation of N-acyl derivatives of aminocombretastatin A-4 (CA-4). Docking studies were carried out in order to find out whether the synthetic derivatives could bind to tubulin at the colchicine site in a conformatio… Show more

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“…Microtubules have also been hypothesized to serve as a cytoplasmic repository for c-MYC proteins [ 68 ]. Additionally, several drugs that disrupt microtubule dynamics decreased c-MYC expression by reducing the cytoplasmic c-MYC reservoir [ 69 ]. Thus, it was fascinating for us to prove whether this reciprocal aspect was true.…”
Section: Discussionmentioning
confidence: 99%
“…Microtubules have also been hypothesized to serve as a cytoplasmic repository for c-MYC proteins [ 68 ]. Additionally, several drugs that disrupt microtubule dynamics decreased c-MYC expression by reducing the cytoplasmic c-MYC reservoir [ 69 ]. Thus, it was fascinating for us to prove whether this reciprocal aspect was true.…”
Section: Discussionmentioning
confidence: 99%