1976
DOI: 10.1007/bf00523961
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Synthesis of N-substituted indoles by extractive alkylation

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Cited by 5 publications
(5 citation statements)
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“…N-Ethylindole was prepared according to a reported method. [14] The solvents (THF and H 2 O) used for the microwave-assisted Suzuki cross-coupling reaction were deoxygenated by bubbling argon through them for 1 h. 1 H and 13 C NMR spectroscopic data were recorded with Bruker DRX-400 and AV-ANCE-500 instruments, using Me 4 Si as an internal standard. All of the signals in the 1 H and 13 C NMR spectra were assigned on the basis of 2D 1 H-1 H COSY, 1 H-13 C HSQC (heteronuclear single quantum correlation), and HMBC experiments.…”
Section: Methodsmentioning
confidence: 99%
“…N-Ethylindole was prepared according to a reported method. [14] The solvents (THF and H 2 O) used for the microwave-assisted Suzuki cross-coupling reaction were deoxygenated by bubbling argon through them for 1 h. 1 H and 13 C NMR spectroscopic data were recorded with Bruker DRX-400 and AV-ANCE-500 instruments, using Me 4 Si as an internal standard. All of the signals in the 1 H and 13 C NMR spectra were assigned on the basis of 2D 1 H-1 H COSY, 1 H-13 C HSQC (heteronuclear single quantum correlation), and HMBC experiments.…”
Section: Methodsmentioning
confidence: 99%
“…Starting indoles 1a, 1d, 1j, and 1f were commercially available, while starting indoles 1b, 1c, 1e, and 1i were obtained by decarboxylation of the corresponding indol-2yl-carboxylic acids [74], and indole 1g was obtained according to [75]. Indoles 1h and 1i were prepared by alkylation of indoles 1f and 1m with benzyl chloride and methyl iodide, respectively, according to [76]. Finally, indoles 1k, 1j и, and 1o were obtained following Chapman et al [77].…”
Section: General Procedures For the Synthesis Of 3-(α-chlorouracil) -Indoles 2a-qmentioning
confidence: 99%
“…Т. пл. 95 -96 °С [11]). енольної ОН-групи вихідних кетонітрилів, що блокує можливість замикання піранового циклу.…”
Section: експериментальна частинаunclassified
“…Згідно з літературними даними 1-бензиліндоліл-3-ацетонітрил (1b) можна одержати алкілуванням індоліл-3-ацетонітрилу (1а) надлишком бензилхлориду в 50 % натрію гідроксиді [11]. Проте під час відтворення зазначеної методики ми одержали лише продукт триалкілування -1,α,α-трибензиліндоліл-3-ацетонітрил.…”
unclassified