Synthesis of Nanocapsules Based on Biosynthesized Nickel Nanoparticles and Potato Starch: Antimicrobial, Antioxidant, and Anticancer Activity

Abstract

Biogenic fabrication of nanoparticles (NPs) by fungi becomes a promising protocol due to effective and environmentally friendly bioprocess. The capsulation of nanoparticles into biopolymer has received considerable attention owing to improve stability. The nickel nanoparticles (Ni-NPs) are synthesized using Penicillium chrysogenum and capsulated into potato starch to produce nanocapsules (Ni-NPs@st) for enhancing their antimicrobial, antioxidant, and anticancer properties. Physicochemical properties of Ni-NPs and Ni-NPs@st are carried out using UV-vis, FTIR, dynamic light scattering (DLS), TEM, and thermal gravimetric analysis (TGA). Results reveal that Ni-NPs@st has antimicrobial activity more than Ni-NPs against Escherichia coli ATCC25922, Bacillus subtilis ATCC605, Candida albicans ATCC90028, Cryptococcus neoformans ATCC 14116, Aspergillus niger RCMB 02724, and A. fumigatus RCMB 02568. Moderate antioxidant activity is recorded using Ni-NPs@st and Ni-NPs with IC50 60 and 97 µg mL −1 , respectively, in contrast to IC50 (7 µg mL −1 ) of ascorbic acid. Cytotoxicity test of Ni-NPs@st and Ni-NPs against Vero cell line indicated that IC50 of Ni-NPs@st and Ni-NPs is 204 and 238 µg mL −1 , respectively. Likewise, moderate anticancer activity of Ni-NPs@st and Ni-NPs toward cancerous cell lines MCF7 is observed with IC50 118 and 217 µg mL −1 , respectively. This study shows prospective biological activities for Ni-NPs@st nanocapsule which can be treat the chronic infections.

Green Biosynthesis of Selenium Nanoparticles Using Orange Peel Waste: Characterization, Antibacterial and Antibiofilm Activities against Multidrug-Resistant Bacteria

“…Nanotechnology is assumed to be the subsequent industrial revolution and is considered to have a tremendous effect on the community, economics, and the common world [5][6][7]. This field possesses great effectiveness in various sites including infection control, biomedicine, industry, wastewater treatment, and agriculture [8][9][10][11][12][13][14][15]. The environmentally friendly approach for the biosynthesis of the nanoparticle is an opportunity for appling it safely in medical fields [16][17][18].…”

Multifunctional Silver Nanoparticles Based on Chitosan: Antibacterial, Antibiofilm, Antifungal, Antioxidant, and Wound-Healing Activities

“…Because of their antimicrobial properties and unique mode of action, specialized NPs provide an attractive alternative to conventional antibiotics in the development of a new generation of antibiotics. Green synthesis of metallic NPs is an economical, easy, and environmentally friendly approach [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Due to their various applications in the medical field, silver NPs (AgNPs) have been proposed as treatment agents to overcome the problem of drug resistance caused by the abuse of antibiotics [ 18 , 19 , 20 ].…”

Green and ecofriendly biosynthesis of selenium nanoparticles using Urtica dioica (stinging nettle) leaf extract: Antimicrobial and anticancer activity

“…[1,2] Nanotechnology is an interdisciplinary field that encompasses a wide range of scientific and technological disciplines, including biomedical, pharmaceutical, environmental, agricultural, advanced structures, chemical sciences, physics, electronics, cotton fabrics, and information technology. [3][4][5][6][7][8][9][10][11][12][13] An emerging research field based on investigating the special characteristics such as size, shape, and distribution of NPs using nanotechnology procedures has been developed recently. [14][15][16][17][18][19][20][21][22][23] Inorganic nanoparticles, whose geometries exhibit fundamentally innovative and improved mechanical, chemical, and biological properties and functioning due to their nanoscale size, have sparked a lot of attention during the last few decades.…”