Synthesis of nanocrystalline calcium hydroxyapatite from calcium saccharates and ammonium hydrogen phosphate

Сафронова, Т. В.; Putlyaev, V. I.; Sergeeva, Albina I.; Kunenkov, E. V.; Tret’yakov, Yu. D.

doi:10.1134/s0012500809060020

Cited by 16 publications

(6 citation statements)

References 3 publications

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“…To prepare nanodimensional and/or nanocrystalline apatites, methods of wet chemical precipitation [62,71,73,86,119,121,155,156,157,160,166,186,187,237,246,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284,285,286,287,288], sol-gel synthesis [30,176,210,211,242,288,289,290,291,292,293,294,295,296,297,298,299], co-precipitation [243,300…”

Section: Synthesis Of the Nanodimensional And Nanocrystalline Calcmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

246

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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Section: Synthesis Of the Nanodimensional And Nanocrystalline Calcmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

246

150

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“…Therefore, various stages of NO evolution were accompanied by the formation of H 2 O or CO 2 , and the overall mass loss was a result of several competing multistage processes involving both calcium phosphate species and ammonium acetate. It has been earlier revealed [18,20,23,24,26] that the reaction by-product consisting of carboxylic acids and their ammonium salts undergoes partial and then complete decomposition at temperatures below 800 • C. Therefore, the calcium phosphates powders containing carboxylic acids or their salts (ammonium, sodium [37], or potassium [38]) heat-treated at 400-800 • C were black-colored due to the formation of carbon or products of partial decomposition of organic substances present in the as-prepared samples.…”

Section: Resultsmentioning

confidence: 96%

“…Obviously, the HPO 4 2− ions can be provided by phosphoric acid or by ammonium hydrophosphates. A variety of calcium compounds, such as CaCO 3 [14], Ca(OH) 2 [10,11], CaCl 2 [15,16], Ca(NO 3 ) 2 [7,8,13,16,17], and the carboxylic acids salts (calcium formate [18], calcium acetate [16,19,20], calcium propionate [21][22][23], calcium lactate [24,25], or calcium saccharates [26,27]) can be used as the source of Ca 2+ ions. Most of the listed carboxylic acids or their salts are used as pH regulators in the food industry [28]; furthermore, these carboxylates, ammonium, and (hydro)phosphate ions are known as components of aqueous buffer solutions [29].…”

Section: Introductionmentioning

confidence: 99%

Calcium Phosphate Powder Synthesized from Calcium Acetate and Ammonium Hydrophosphate for Bioceramics Application

et al. 2018

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Calcium phosphate powder was synthesized at room temperature from aqueous solutions of ammonium hydrophosphate and calcium acetate without pH adjusting at constant Ca/P molar ratio 1.5. Phase composition of the as-synthesized powder depended on the precursors concentration: At 2.0 M of calcium acetate in the starting solution, poorly crystallized hydroxyapatite was formed, 0.125 M solution of calcium acetate afforded brushite, and the powders synthesized from 0.25-1.0 M calcium acetate solutions were mixtures of the mentioned phases. Firing at 1100 • C led to complete elimination of the reaction by-products, yet the phase composition of the annealed compacted samples was the following: When 2.0 M solution of calcium acetate was used, the obtained ceramics consisted of β-Ca 3 (PO 4 ) 2 , whereas at 0.125 to 1.0 M of calcium acetate, the ceramics was a mixture of β-Ca 3 (PO 4 ) 2 and β-Ca 2 P 2 O 7 . Synthesized calcium phosphate powders can be used as the powdered precursors for biocompatible bioresorbable composite ceramics production.

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“…Combinations of Ca(OH) 2 and (NH 4 ) 2 HPO 4 were selected for the removal of boron from alkaline solution. In this method, using (NH 4 ) 2 HPO 4 as phosphate salt of removal reagent, ammonia is produced [27]. Time required to remove boron was 20 min by this method, on the other 1 day by the conventional one for the concentration of remaining boron to become below 1 mg/L.…”

Section: Discussionmentioning

confidence: 99%

Removal of boron from wastewater by the hydroxyapatite formation reaction using acceleration effect of ammonia

Yoshikawa

Sasaki

Endo

2012

Journal of Hazardous Materials

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Synthesis of nanocrystalline calcium hydroxyapatite from calcium saccharates and ammonium hydrogen phosphate

Cited by 16 publications

References 3 publications

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Calcium Phosphate Powder Synthesized from Calcium Acetate and Ammonium Hydrophosphate for Bioceramics Application

Removal of boron from wastewater by the hydroxyapatite formation reaction using acceleration effect of ammonia

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