Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus

Pan, Dipanjan; Caruthers, Shelton D.; Senpan, Angana; Yalaz, Ceren; Stacy, Allen J.; Hu, Grace; Marsh, Jon N.; Gaffney, Patrick J.; Wickline, Samuel A.; Lanza, Gregory M.

doi:10.1021/ja201918u

Cited by 47 publications

(35 citation statements)

References 37 publications

(18 reference statements)

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“…Nanoformulations based on these biological metal ions (M 2+ = Mn 2+ , Co 2+ , Ni 2+ , and Cu 2+ ion etc.) have also been reported for MRI 49–51. Similar to Gd nanoformulations, aggregation of large amount of M 2+ ions or their derivatives in a nanoparticle can significantly increase the ionic relaxivity and the overall detection sensitivity.…”

Section: Biological Metal‐based Nanoparticulate Mri Contrast Agentsmentioning

confidence: 86%

Nanoformulations for molecular MRI

Louie

2012

WIREs Nanomed Nanobiotechnol

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Nanoscale contrast agents have shown the ability to increase the detection sensitivity of MRI by several orders of magnitude, endowing this traditionally macroscopic modality with the ability to observe unique molecular signatures. Herein, we describe three types of nanoparticulate contrast agents: iron oxide nanoparticles, gadolinium-based nanoparticles, and bio-essential manganese, cobalt, nickel, and copper ion-containing nanoformulations. Some of these agents have been approved for clinical use, but more are still under development for medical imaging. The advantages and disadvantages of each nanoformulation, in terms of intrinsic magnetism, ease of synthesis, and biodistribution, etc. are discussed.

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Section: Biological Metal‐based Nanoparticulate Mri Contrast Agentsmentioning

confidence: 86%

Nanoformulations for molecular MRI

Louie

2012

WIREs Nanomed Nanobiotechnol

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“…As opposed to technologies where local injection of gold particles limits treatment cost, systemic therapies for thrombus detection will require orders of magnitude more gold and increase treatment cost substantially. To address this issue, high-density organometallic suspensions of divalent copper in lipid-encapsulated nanoparticles were developed for fibrin imaging with MRI 131 and then used for systemic photoacoustic imaging and anti-angiogenic drug delivery (fumagillin prodrug) targeted to the sparse αvβ3-integrin receptor expressed by nascent neovessel sprouts. 132 These copper-rich nanoparticles demonstrated NIR photoacoustic reflectively similar to gold GNB.…”

Section: Alternative Modalities For Molecular Imaging Of Thrombusmentioning

confidence: 99%

An unmet clinical need: The history of thrombus imaging

Lanza

Cui

Schmieder

et al. 2019

Journal of Nuclear Cardiology

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Robust thrombus imaging is an unresolved clinical unmet need dating back to the mid 1970s. While early molecular imaging approaches began with nuclear SPECT imaging, contrast agents for virtually all biomedical imaging modalities have been demonstrated in vivo with unique strengths and common weaknesses. Two primary molecular imaging targets have been pursued for thrombus imaging: platelets and fibrin. Some common issues noted over 40 years ago persist today. Acute thrombus is readily imaged with all probes and modalities, but aged thrombus remains a challenge. Similarly, anti-coagulation continues to interfere with and often negate thrombus imaging efficacy, but heparin is clinically required in patients suspected of pulmonary embolism, deep venous thrombosis or coronary ruptured plaque prior to confirmatory diagnostic studies have been executed and interpreted. These fundamental issues can be overcome, but an innovative departure from the prior approaches will be needed.

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“…Metalation can also impart interesting properties independent of the porphyrins' photonic properties. Mn 3+ and Cu 2+ are capable of affecting the magnetic relaxation times of the surrounding water molecules in a strong magnetic field, such as that used in magnetic resonance imaging (MRI) [72][73][74][75][76][77]. This allows paramagnetic porphyrins to act as MRI contrast agents.…”

Section: Discussionmentioning

confidence: 99%

Porphysome nanoparticles: Tailoring treatments with nature’s pigments

MacDonald

Zheng

2014

Photonics &Amp; Lasers in Medicine

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Porphysomes are an emerging class of photonic nanoparticles formed from the self-assembly of porphyrin-lipid conjugates. They retain the multifunctional properties of their porphyrin building-blocks but also have unique properties emerging from the nanostructure itself. Porphysomes are able to act in a number of photonic modalities, from diagnostic fluorescence and photoacoustic imaging, to photodynamic and photothermal therapies. This flexibility enables customizable interventions with potential in the burgeoning field of personalized medicine. Here, we profile early porphysome-like liposomes, true porphysomes, as well as newer porphysome derivatives. We discuss the current applications and future outlook for these multimodal theranostic nanoparticles.

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Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus

Cited by 47 publications

References 37 publications

Nanoformulations for molecular MRI

Nanoformulations for molecular MRI

An unmet clinical need: The history of thrombus imaging

Porphysome nanoparticles: Tailoring treatments with nature’s pigments

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