Synthesis of nanostructured materials in inverse miniemulsions and their applications

Cao, Zhihai; Ziener, Ulrich

doi:10.1039/c3nr03190j

Cited by 52 publications

(35 citation statements)

References 98 publications

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“…In recent years, inverse miniemulsion polymerization technique has been proven to be a promising and effective technique to prepare various hydrophilic polymeric nanogels . In typical inverse miniemulsion polymerization systems, many polar liquid droplets are homogenously dispersed in a low‐polarity continuous phase . Hydrophilic monomers are pre‐introduced to the dispersed phase, and polymeric nanogels are formed through droplet nucleation during the inverse miniemulsion polymerization .…”

Section: Introductionmentioning

confidence: 97%

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Preparation of thermoresponsive poly(N‐vinylcaprolactam‐co‐2‐methoxyethyl acrylate) nanogels via inverse miniemulsion polymerization

Gao

et al. 2019

J of Applied Polymer Sci

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Stimuli-responsive polymeric nanogels hold great potential in biological applications. In this work, thermoresponsive polymeric nanogels were conveniently prepared through inverse miniemulsion polymerization of two monomers with a good biocompatibility, N-vinylcaprolactam and 2-methoxyethyl acrylate. A macromolecular crosslinker, poly(ethylene glycol) dimethacrylate (PEGDMA), was used to achieve a better thermoresponsiveness, compared with low-molecular-weight crosslinkers. The prepared poly(Nvinylcaprolactam-co-2-methoxyethyl acrylate) (poly(NVCL-co-MEA)) nanogels could be well redispersed in aqueous systems, displaying a reversible thermoresponsive transition behavior. The influences of the synthesis parameters including the emulsifier content, PEGDMA content, and monomer composition on the particle properties of poly(NVCL-co-MEA) nanogels both in inverse emulsions and in aqueous dispersions were systematically investigated. Furthermore, the impacts of the monomer composition and PEGDMA content on the thermoresponsiveness of poly(NVCL-co-MEA) nanogels were also studied. Promisingly, the introduction of MEA monomeric units to the copolymer chains only slightly reduced the thermoresponsiveness of poly(NVCL-co-MEA) nanogels. This feature allows to improve the biocompatibility of polymeric nanogels by using MEA as the comonomer without need to compromise the thermoresponsiveness of nanogels. based nanogels, including aqueous dispersion polymerization 24,34,35 and emulsion polymerization. 26,27,36 For instance, thermo-and pH-responsive nanogels based on poly(Nvinylcaprolactam-co-acetoacetoxy methacrylate) were synthesized Additional Supporting Information may be found in the online version of this article.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Preparation of thermoresponsive poly(N‐vinylcaprolactam‐co‐2‐methoxyethyl acrylate) nanogels via inverse miniemulsion polymerization

Gao

et al. 2019

J of Applied Polymer Sci

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“…In addition, mesoporous CeO 2 nanoparticles have been synthesized with cerium nitrate salts as precursor in inverse miniemulsions [26]. Hydrophilic salts as lipophobes are inherently required in inverse miniemulsions to improve the droplet stability [19]. Therefore, it is convenient to incorporate hydrophilic salts in polymeric [27,28] or inorganic [22] matrices through the inverse miniemulsion technique.…”

Section: Introductionmentioning

confidence: 99%

“…Inverse miniemulsions in which the polarity of the dispersed phase is higher than that of the continuous phase have been widely used to prepare hydrophilic nanoparticles or nanocomposite particles [19]. The preparation of a variety of different inorganic particles and capsules in inverse miniemulsions has been reported [20].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Au/TiO2 nanocomposite particles with high visible-light photocatalytic activity in inverse miniemulsions

et al. 2014

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Au/amorphous TiO 2 nanocomposite particles with high visible-light photocatalytic activity were conveniently prepared in inverse miniemulsions. The materials were synthesized through a combination of a sol-gel process and in situ reduction of HAuCl 4 by hydrazine to Au nanoparticles in the nanocomposite particles. The photocatalytic activity of the assynthesized Au/amorphous TiO 2 nanocomposite particles is much higher than that of the Au/anatase TiO 2 and Au/rutile TiO 2 nanocomposite particles prepared by calcination. Therefore, no further heat treatments are required to achieve visiblelight photocatalytic active catalysts. The loading of Au in the nanocomposite particles could be conveniently tuned by varying the HAuCl 4 loading in the dispersed phase of the inverse miniemulsions. Only a small amount of Au was required to achieve a high photocatalytic activity. The size, particle morphology, TiO 2 phase, optical property, elemental content and distribution, and pore properties of the Au/TiO 2 nanocomposite particles were systematically characterized by dynamic light scattering, transmission/scanning electron microscopy, X-ray diffraction, Raman spectroscopy, UV-vis spectroscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and N 2 sorption measurements.

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“…Reprecipitation (RP), [ 10 ] self-assembly, [ 11 ] ion-association, [ 12 ] condensation, [ 13 ] microemulsion (ME), [ 14 ] and laser ablation (LA) [ 15 ] are some methods used to fabricate O-NPs. For the preparation of O-NPs comprising luminescent properties, the most commonly employed methods are RP and ME.…”

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Two‐Photon Imaging of a Cellular Line Using Organic Fluorescent Nanoparticles Synthesized by Laser Ablation

Aparicio-Ixta

Alba-Rosales

Ramos‐Ortíz

et al. 2016

Part & Part Syst Charact

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A comparative study of the optical properties of organic fl uorescent nanoparticles fabricated by laser ablation (NPs-LA), reprecipitation (NPs-RP), and microemulsion (NPs-ME) methods is presented. These nanoparticles contain a fl uorene-based p-conjugated molecule (BT2). Distinctive electronic transitions are observed in samples due to the specifi c way in which the molecule BT2 is assembled in each type of nanoparticles; for instance, transitions involved in absorption and emission spectra of NPs-LA result in blueshifting with respect to the molecular solution of BT2, whereas redshifting is observed in NPs-RP and NPs-ME. Further, the results show that under infrared excitation, the aqueous suspensions of NPs-LA exhibit the highest fl uorescence induced by two-photon absorption (≈790 GM at 740 nm), as well as the best photostability, compared with aqueous suspensions of NPs-RP and NPs-ME. The nanoparticles synthetized by the three aforementioned methods are employed as exogenous agents for the visualization of human cervical cancer cell line (HeLa) using confocal and two-photon microscopy. Under similar experimental conditions, it is found that microscopy images of the best quality are obtained with NPs-LA. These results show that laser ablation is a suitable technique for the fabrication of organic fl uorescent nanoparticles used as contrast agents for in vitro fl uorescence microscopy.O-NPs have been successfully exploited as contrast agents (fl uorescent markers) for in vitro and in vivo studies in cellular lines and organisms, [ 5 ] medical imaging, [ 6 ] diagnostic purposes, [ 7 ] and positive confi rmation of the site-specifi c delivery of a drug with the goal of obtaining effective treatment of diseases. [ 8,9 ] Some advantages obtained by using organic nanostructures are: i) stability of fl uorescent organic materials in aqueous suspensions, ii) reduced toxicity, iii) decreased degradation, and iv) selectivity toward specifi c targets.Simple and versatile strategies of fabrication have been used to obtain O-NPs with different morphologies and optical properties in aqueous media. Reprecipitation (RP), [ 10 ] self-assembly, [ 11 ] ion-association, [ 12 ] condensation, [ 13 ] microemulsion (ME), [ 14 ] and laser ablation (LA) [ 15 ] are some methods used to fabricate O-NPs. For the preparation of O-NPs comprising luminescent properties, the most commonly employed methods are RP and ME. [ 16,17 ] LA has also been used to obtain fl uorescent O-NPs, [18][19][20] and some basic characterization of their optical properties has been performed, but to the best of our knowledge, demonstration of their use in the context of biophotonic applications, i.e., imaging of biological samples, has

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Synthesis of nanostructured materials in inverse miniemulsions and their applications

Cited by 52 publications

References 98 publications

Preparation of thermoresponsive poly(N‐vinylcaprolactam‐co‐2‐methoxyethyl acrylate) nanogels via inverse miniemulsion polymerization

Preparation of thermoresponsive poly(N‐vinylcaprolactam‐co‐2‐methoxyethyl acrylate) nanogels via inverse miniemulsion polymerization

Preparation of Au/TiO2 nanocomposite particles with high visible-light photocatalytic activity in inverse miniemulsions

Two‐Photon Imaging of a Cellular Line Using Organic Fluorescent Nanoparticles Synthesized by Laser Ablation

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