Synthesis of Nanostructured Mixed-Valence Fe(II,III) Metal-Organic Framework and Its Application in Electrochemical Sensing of Amoxicillin

Abstract

The study reports the development of a nanostructured mixed-valence Fe(II)Fe(III)BTC metal-organic framework (BTC = 1,3,5-benzenetricarboxylate) modified carbon paste electrode as a novel sensor for the amoxicillin detection in aqueous solutions using square wave voltammetry. The physicochemical properties of FeBTC were characterized using X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy. These techniques revealed that FeBTC has a surface area of 1211 m2/g, a total pore volume of 1.46 cm3/g, particle sizes ranging from 10 to 20 nm, and a mixed-valence structure. Furthermore, SEM, TEM, and energy-dispersive X-ray spectroscopy showed homogeneous distribution of FeBTC throughout the modified electrode. The electrochemical study showed that the mixed-valence FeBTC improved the electron transfer capabilities of the electrode. Under optimal conditions, the modified electrode exhibited a significant increase in peak height compared to the unmodified electrode (4.6 times higher), with an acceptable reproducibility of 4.88% relative standard deviation. The linear range of the sensor was 1-100 µM with a good coefficient of determination of 0.9985, and a detection limit of 0.107 µM. Additionally, the sensor demonstrated excellent performance with the satisfactory recoveries and a good correlation with LC-MS/MS analysis.

A Sensitive Electrochemical DNA Biosensor for Determination of Anti-Cancer Drug Gemcitabine Based on an AuNPs/MWCNTs/Carbon Paste Electrode

“…[23][24][25] To enhance the performance of CPE, various modifiers can be added to the electrode. Many types of modified CPE have been fabricated and used to improve the sensitivity and stability of sensors, using different nanomaterials such as carbon nanotubes, 26,27 metal nanoparticles, 28 metal organic frameworks, 29 conductive polymers, 30 nanowires, 31 quantum dots (QDs), 32 magnetic nanoparticles, 33 and gold nanoparticles (AuNPs). 34 Among these nanomaterials, carbon nanotubes (CNTs) and AuNPs are the most widely explored ones because of their exceptional properties, which can be applied in various fields, such as sensing, detection, and imaging.…”