Synthesis of New 1, 10‐Phenanthroline Analogs as Potent Antimicrobial Agents Using Montmorillonite K‐10 as Catalyst

Pagadala, Ramakanth; Chidurala, Praveen; Jetti, Venkateshwarlu; Meshram, Jyotsna S.; Maddila, Suresh; Jonnalagadda, Sreekantha B.

doi:10.1002/jhet.2058

Cited by 8 publications

(4 citation statements)

References 49 publications

(13 reference statements)

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“…Montmorillonite K10 (MMT-K10) is a layered aluminasilicate clay which has many applications in synthetic organic reactions [24][25][26][27][28][29]. The featured properties of montmorillonite are as follows: low cost, ease of handling, non-corrosiveness, suitable surface area (250 m 2 /g), and reusability.…”

Section: Introductionmentioning

confidence: 99%

Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

Safari

Sadeghi

2016

Res Chem Intermed

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Section: Introductionmentioning

confidence: 99%

Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

Safari

Sadeghi

2016

Res Chem Intermed

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“…Mont. K10 clay is an economically feasible, non‐corrosive solid catalyst exhibiting numerous benefits, including easier handling and workup, strong acidity, low cost, milder reaction conditions, excellent yields, high selectivity, and regeneration [64–68] …”

Section: Introductionmentioning

confidence: 99%

“…K10 clay is an economically feasible, non-corrosive solid catalyst exhibiting numerous benefits, including easier handling and workup, strong acidity, low cost, milder reaction conditions, excellent yields, high selectivity, and regeneration. [64][65][66][67][68] We, herein report a facile multicomponent reaction of aldehyde, malononitrile, and thiophenol catalyzed by mont. K10 clay to afford substituted 2-Amino-3,5-dicarbonitrile-6-thiopyridines in moderate to high yields.…”

Section: Introductionmentioning

confidence: 99%

Montmorillonite K10 Clay Accelerated One‐Pot Multicomponent Synthesis of Substituted 2‐Amino‐3,5‐dicarbonitrile‐6‐phenylsulfanylpyridines: Experimental and Theoretical Investigation

Sharma,

Sinha

2023

ChemistrySelect

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Abstract2‐Amino‐3,5‐dicarbonitrile‐6‐phenylsulfanylpyridines occupy a prominent place among the physiologically and biologically active scaffolds owing to their therapeutic applications in the treatment of Parkinson's disease, asthma, urinary incontinence, kidney disease, the Hepatitis B infections, Creutzfeldt–Jacob disease, cancer, hypoxia/ischemia and epilepsy. A one‐pot, multicomponent condensation of aldehydes, malononitrile, and thiophenol catalyzed by Montmorillonite K10 clay afforded 2‐amino‐3,5‐dicarbonitrile‐6‐phenylsulfanylpyridines in good to excellent yields. All the products could be well characterized on the basis of spectral studies. The catalyst could be recycled three times without affecting the yields and even in the fourth recycling of the catalyst, the yield decreases marginally. This approach manifests environmentally benign feasibility in contexts of enhanced yields, milder conditions, short reaction times, and reusability of the catalyst. A theoretical study of a synthesized compound at the B3LYP/6–31 + G (d) level is additionally reported. Following the computation of the fundamental vibrational wavenumbers and intensities, it became evident that the observed and calculated wavenumbers were in perfect accord. Employing the same DFT level, Frontier molecular orbital (HOMO‐LUMO) energies, global reactivity descriptors, and molecular electrostatic potential were estimated for assessing the reactivity and possible sites for electrophilic and nucleophilic molecules. The outcomes prove that the compound exhibits significant kinetic stability.

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“…Recent progresses in heterogeneous catalysis demonstrate the utility of K10 clay as a suitable solid acid catalyst or support for simple organic transformations namely Fries rearrangement, Fischer-Hepp rearrangement, Orton rearrangement and many more [64]. Mont K-10 clay is an economically feasible, non-corrosive solid catalyst exhibiting numerous benefits, including easier handling and workup, strong acidity, low cost, milder reaction conditions, excellent yields, high selectivity and regeneration [65][66][67][68][69].…”

Section: Introductionmentioning

confidence: 99%

A one-pot multicomponent K-10 clay catalyzed synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines

Sharma¹,

Sinha²,

Bansal³

2022

Preprint

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2-Amino-3,5-dicarbonitrile-6-thiopyridines occupy a prominent place among the physiologically and biologically active scaffolds owing to their therapeutic applications in the treatment of Parkinson’s disease, asthma, urinary incontinence, kidney disease, the Hepatitis B Foundation infections, Creutzfeldt–Jacob disease, cancer, hypoxia/ischemia and epilepsy. A one-pot, multicomponent condensation of aldehydes, malononitrile and thiophenol catalyzed by Montmorillonite K-10 clay afforded 2-amino-3,5-dicarbonitrile-6-thiopyridines in good to excellent yields. All the products could be well characterized on the basis of spectral studies. The catalyst could be recycled three times without affecting the yields and even in the fourth recycling of the catalyst, the yield decreases marginally. This approach manifests environmentally benign feasibility in contexts of enhanced yields, milder conditions, short reaction times and reusability of the catalyst.

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Synthesis of New 1, 10‐Phenanthroline Analogs as Potent Antimicrobial Agents Using Montmorillonite K‐10 as Catalyst

Cited by 8 publications

References 49 publications

Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

Montmorillonite K10 Clay Accelerated One‐Pot Multicomponent Synthesis of Substituted 2‐Amino‐3,5‐dicarbonitrile‐6‐phenylsulfanylpyridines: Experimental and Theoretical Investigation

A one-pot multicomponent K-10 clay catalyzed synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines

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