Synthesis of new 1,2-Benzothiazin-3-one Derivatives Designed as Dual Cyclooxygenase-2 and 5-Lipooxygenase Inhibitors

Synthesis, Characterization and Anticorrosion Studies of New Homobimetallic Co(II), Ni(II), Cu(II), and Zn(II) Schiff Base Complexes

“…The two weak intensity bands at 3090 and 2860 cm -1 correspond to m(C-H) ar and m(C-H) aliph stretching vibrations. The stretching vibration observed at 1272 cm -1 is due to m(C-O) [25]. Also, the strong band at 1030 cm -1 is assigned to m(NO) oxime [26].…”

Nimesulide is a Selective COX-2 Inhibitory, Atypical Non-Steroidal Anti-Inflammatory Drug

“…3b) [25][26][27]. Before the COX-2 discovery, the anti-inflammatory effect of nimesulide had been attributed to its radical scavenger behavior, which may be explained by the presence of the paranitrosulfonylaminophenyl unit in its structure [28]. After the COX-2 discovery, selective inhibition of COX-2 and the antiinflammatory effect of nimesulide were mainly attributed to the presence of the methansulphonamide group [29].…”

Proline-Cu Complex Based 1,3,5-Triazine Coated on Fe3O4 Magnetic Nanoparticles: A Nanocatalyst for the Knoevenagel Condensation of Aldehyde with Malononitrile

“…The final step is accompanied by the elimination of water. 8 This kind of reaction is attractive and important due to its presence in total synthesis, 15−17 drugs, 18 and one-step synthesis of several molecules. 19,20 For instance, as the first step to synthesize (S)-(+)-3-aminomethyl 5-methylhexanoic acid, the Knoevenagel condensation was carried out between diethyl malonate and valeraldehyde.…”

“…The final step is accompanied by the elimination of water . This kind of reaction is attractive and important due to its presence in total synthesis, − drugs, and one-step synthesis of several molecules. , For instance, as the first step to synthesize ( S )-(+)-3-aminomethyl 5-methylhexanoic acid, the Knoevenagel condensation was carried out between diethyl malonate and valeraldehyde. , Also, many other drugs such as pioglitazone, atorvastatin, and coartem have been prepared by this condensation. In recent years, various catalysts were developed for the Knoevenagel condensation such as {[(CH 3 ) 2 NH 2 ] 2 [CaZn­(TDP)­(H 2 O)]·3DMF·3H 2 O} n (NUC-21), {(Me 2 NH 2 ) 4 [Eu 4 (DDAC) 3 (HCO 2 )­(OH 2 ) 2 ]·8DMF·9H 2 O} n (NUC-41), {(Me 2 NH 2 ) 2 [Mn 2 (TDP)­(H 2 O) 2 ]·3H 2 O·3DMF} n (NUC-31; DMF = N , N -dimethylformamide), {(Me 2 NH 2 )­[Tm 3 (BDCP) 2 (H 2 O) 3 ]·4DMF·H 2 O} n (simplified as NUC-25), {[Ba 3 Zn 4 (TDP) 2 (HCO 2 ) 2 (OH 2 ) 2 ]·7DMF·4H 2 O} n (NUC-27), acid–base bifunctional sulfonated graphitic carbon nitride (S-g-C 3 N 4 ), heterogeneous catalysts, imidazole- stimulated self-assembly of polyoxovanadate cluster organic framework, MgAl-LDH/ZIF-8, potassium-functionalized graphitic carbon nitride supported on reduced graphene oxide (KGCN-RGO), metal–organic framework (MOF), silica- l -proline, Fe 3 O 4 @SiO 2 -3 N, montmorillonite KSF, Ce­(III) and Lu­(III) metal–organic frameworks (MOFs), nickel metal–organic framework (MOF), H 2 O/1,4-diazabicyclo­[2.2.2]­octane (DABCO), organic compounds, papain, lipase, composite oxides, , Nmm-based ionic liquids, ethylenediammonium diacetate, phosphane, hydroquinone and benzoquinone, l -proline, magnesium oxide (MgO), and iron .…”