Synthesis of New 1,4-Benzodioxanуl-1,2,4-triazole Derivatives

Abstract

The reaction of 5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol with N-substituted chloroacetic acid amides obtained by condensation of chloroacetyl chloride with various primary amines furnished a series of S-amidomethyl derivatives. The corresponding thiazolotriazolone prepared from 2-[5-(1,4-benzodioxan-2yl)-4H-1,2,4-triazol-3-ylthio]acetic acid reacted with aromatic aldehydes to form arylidene derivatives.

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

“…The authors [16] reported the synthesis of new derivatives of 1,2,4-triazole with benzodioxane in the fifth position. The desired amidomethylthio derivatives were synthesized by replacing the potassium salt of triazolotyol with various primary arylalkylamines [16] (Fig. 15).…”

“…Transformation of 1,4-benzodioxanyl-1,2,4-triazoles [16] According to the authors [16], derivatives of 5-(1,4-benzodioxanyl)-1,2,4-triazole-3-thiol have antitumor effects. The compounds also showed antimicrobial and antiviral effects.…”