Synthesis of new 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial, antifungal and antitubercular agents

Joshi, S. D.; More, Yogesh W.; Vagdevi, H. M.; Vaidya, V. P.; Gadaginamath, G. S.; Kulkarni, Vaishali

doi:10.1007/s00044-012-0112-0

Cited by 27 publications

(18 citation statements)

References 15 publications

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“…When treated with benzohydrazide, acetophenone, carbon disulfide or different aldehydes in alcoholic medium, instead of acetone, a variety of different compounds are obtained, most of them sharing promising antibacterial and anti-tubercular properties [71]. Elaborating on this work, the authors have more recently reported the synthesis of another class of compounds, namely 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogues [112]. The resultant systems are considered to be potential antibacterial, antifungal and antitubercular agents.…”

Section: Modification and Addition Of Functional Groups In Existing Pmentioning

confidence: 97%

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Domagala

Jarosz

Łapkowski

2015

European Journal of Medicinal Chemistry

127

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Section: Modification and Addition Of Functional Groups In Existing Pmentioning

confidence: 97%

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Domagala

Jarosz

Łapkowski

2015

European Journal of Medicinal Chemistry

127

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“…Pigmentasyon, antimikrobiyal etki, enzimatik süreçler ve diğer bazı önemli biyolojik faaliyetlerde rol oynayan moleküllerde yer alırlar. Hint yağı bitkisi, su yasemini ve diğer bazı bitkilerden elde edilebilen dimetilpirol formlarının ilaç ve antimikrobiyal etkileri günümüzde araştırılmaya başlanmıştır [20,25,26]. Bununla beraber dimetilpirol formlarının F. culmorum üzerine etkisi bilinmemektedir.…”

Section: Tartişma Ve Sonuçunclassified

2,4-Dimetilpirol’ün Başak Yanıklığı Hastalığı Etmeni Fusarium culmorum’un Üzerine Etkilerinin İncelenmesi

Sefer

Yörük

Develi

et al. 2017

International Journal of Secondary Metabolite

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Özet: Bitki patojeni Fusarium culmorum dünyada ve ülkemizde tahıllar üzerinde kök çürüklüğü ve başak yanıklığı başta olmak üzere çeşitli hastalıklara neden olmaktadır. Bu çalışmada F. culmorum ile mücadele kullanılabilecek yeni ve potansiyel bir ajan olarak 2,4-Dimetilpirol'ün patojen üzerindeki etkileri incelenmiştir. Bu amaçla farklı konsantrasyonlarda 2,4-Dimetilpirol (0, 0.5, 1, 2 ve 4 mg mL -1 ) uygulanmış F. culmorum 20F izolatında artan konsantrasyonlarda doğrusal büyüme oranındaki (DBO) değişim incelenmiş ve kontrol ve deney grupları arasında anlamlı bir düşüş olduğu görülmüştür. Ayrıca seksüel üreme ve hücre çeperi bütünlüğünden sorumlu Mgv1 geninin anlatımı gerçek zamanlı kantitatif polimeraz zincir reaksiyonu (k-PZR) ve ters transkripsiyon PZR (RT-PZR) ile incelenmiştir. Deney gruplarında kontrol gruplarına göre Mgv1 geni için 5.21±0.05x10 2 kat artma saptanmıştır. Elde edilen bulgulara göre 2,4-Dimetilpirol'ün, F. culmorum türünde potansiyel bir antifungal etkili ajan olabileceği gösterilmiştir. İleriki çalışmalarda bu ajanın tarladaki fungal biyokütlenin ve toksin üretiminin azaltılmasını sağlayarak hastalık ile mücadelede yeni bir yaklaşım olarak kullanılabileceği düşünülmektedir. Anahtar Kelimeler: Antifungal; Başak Yanıklığı; Fusarium; 2,4-Dimetilpirol Investigation of the Effects of 2,4-Dimethylpyrrole on Fusarium culmorum Causal Agent of Head Blight DiseaseReceived: 31 January 2017 -Revised: 11 April 2017 -Accepted: 19 April 2017 Abstract: Fusarium culmorum, a phytopathogen, cause several diseases including root rot and head blight on cereals in worldwide and our country. In this study, effects of 2,4-Dimethylpyrrole, as a novel and potential agent on pathogen which can be used in fight with F. culmorum were investigated. For this purpose, alteration in linear growth rate (LGR) in F. culmorum 20F isolate, subjected to different concentrations of 2,4-Dimethylpyrrole (0, 0.5, 1, 2, 4 mg mL -1

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“…In our previous study, we have synthesized various heterocycles as antiinfective agents (Figure 1), where we determined that pyrrole and thiadiazole derivatives are good antitubercular and antimicrobial agents. [23][24][25][26][27] Keeping this in mind, we report here new prototype hybrid molecules …”

Section: Introductionmentioning

confidence: 99%

Pyrrolyl thiadiazoles as Mycobacterium tuberculosis inhibitors and their in silico analyses

Joshi¹,

More²,

Sorathiya³

et al. 2015

RRMC

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A novel series of pyrrolyl thiadiazoles was synthesized and tested for antimycobacterial activity against the Mycobacterium tuberculosis H 37 Rv strain, using the microplate Alamar blue assay method. Molecular docking and in vitro minimum inhibitory concentration assays revealed that these molecules can be primarily screened for ENR inhibition, using the score values and H-bond interactions with amino acid residues Tyr158, Met98, and cofactor NAD + , which are the key interactions. For most of the molecules, hydrophobic interaction is the key factor affecting their antitubercular activity. The activity of -OCH 3 , -NO 2 , -F, pyridine, and sulfonamide substituted derivatives was better than that of -CH 3 , -NH 2 , -Cl, and -Br substituted derivatives, as per experimental and docking studies. Molecular modeling studies are in agreement with their biological evaluations.

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Synthesis of new 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial, antifungal and antitubercular agents

Cited by 27 publications

References 15 publications

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

2,4-Dimetilpirol’ün Başak Yanıklığı Hastalığı Etmeni Fusarium culmorum’un Üzerine Etkilerinin İncelenmesi

Pyrrolyl thiadiazoles as Mycobacterium tuberculosis inhibitors and their in silico analyses

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