Synthesis of New 4-Oxo-Tetrahydroindol Derivatives by Using Chemical and Microbial Biotransformation Methods

Recent Developments on Catalyst‐Free, Visible‐Light‐Triggered Synthesis of Heterocyclic Scaffolds and Their Mechanistic Study

“…Molindone, a drug which comprises of tetrahydroindole scaffolds, is used for therapy of schizophrenia and other psychoses. [24] Ansari et al reported a highly efficient visible lightmediated one-pot strategy for the synthesis of highly functionalized 4-oxo-tetrahydroindoles (7) by the reaction of dimedone (4), phenacyl bromide (5) and aromatic amines (6) in ethanol : water medium at room temperature without any catalyst (Scheme 3). [25] During the screening of light sources and intensities, 22 W CFL was found to be the best source of light with product yield of 92 % within a short reaction time (3.5-4 hours) and only a trace amount of the product was obtained when the reaction was carried out in the absence of light even after 10 hours which confirmed the vital role of light.…”