Synthesis of new 5-aryl tetrazoline and evaluation of their antifungal and antibacterial activity

Abstract

The research resulted in the production of new tetrazoline derivatives. Firstly; the reaction of N-acetyl chloro cyclic imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) were reacted with different aromatic aldehydes to give Schiff bases (3-10). The compounds of N-( 2-chloro acetyl) cyclic imides were reacted with sodium azide to give N-(azido acetyl) cyclic imides (11,12). Finally, the reaction of the prepared Schiff bases compounds with azide compounds and cyclization to give 5-aryl tetrazoline on cyclic imides (13-20). The prepared compounds were characterized by FT-IR and some of them by 1 H NMR, melting point, and were studied the effects of the preparing compounds on some strains of bacteria and fungi.

Preparation, Characterization, Antioxidant and Antibacterial Studies of New Metal (II) Complexes with Schiff Base for 3-amino-1-phenyl-2- pyrazoline-5-one

“…The creation of stable DPPH decreased the intensity of the DPPH band, demonstrating the ability of metal complexes and ascorbic acid (Vitamin C used as a standard) to scavenge free radicals. 29 Increased antioxidant activity is indicated by a decrease in absorbance and a decrease in the IC 50 value. 30 The IC 50 values of the test compounds were observed has a stronger scavenging activity.…”

Biological Evaluation and Antioxidant Studies of Nio, Pdo and Pt Nanoparticles Synthesized from a New Schiff Base Complexes

“…Scavenger Activity % = 100 -(A0 -At \ A0) * 100 Where A0 is the absorbance of DPPH, it represents the absorbance of the extracted solution with DPPH. As for the effectiveness of nickel and palladium oxide particles and platinum nanoparticles, IC50 cannot be estimated because the higher concentration and the lower the effectiveness [32].…”

Synthesis, Characterization, Antimicrobial and Antioxidant Study of New Complexes Schiff Base Derived from 2, 5-diChloroaniline

“…Additionally, the lipophilicity of the complexes is increased due to the delocalization of electrons with a charge of over the entire chelate ring as well as the large ring size of the ligands moiety. 27,28 Evaluation of Antioxidant Activity by DPPH Radical Scavenging Method:…”