Synthesis of new acridines and hydrazones derived from cyclic β-diketone for cytotoxic and antiviral evaluation

El‐Sabbagh, Osama I.; Rady, Hanaa M.

doi:10.1016/j.ejmech.2009.04.001

Cited by 101 publications

(69 citation statements)

References 19 publications

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess awide range of biological and pharmaceutical activities such as antimicrobial, anti-convulsant, antifungal,anticancer, antitubercular, antiviral,antibacterial, and antioxidant activities [1][2][3][4][5][6][7][8].M eanwhile,h ydrazones have also interesting properties because of the presence of several coordinations ites,a nd thus theirm etal complexes are important for their possible biological applications [9].T he thiazole ring is present in various biologically active molecules. Thiazoles and their derivatives possessa ctivities such as antitumor, antiviral, and antibacterial [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess a wide range of biological and pharmaceutical activities such as antimicrobial [1], anti-convulsant [2], antifungal [3], anticancer [4], antitubercular [5], antiviral [6], antibacterial [7], and antioxidant [8] activities. Meanwhile, hydrazones have also interesting properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [9].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Guo

Miao

2013

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThe title compound was obtained from 2-amin-3-chloropyridine according to the literature method [14]. Single crystals suitable for X-ray diffraction were obtained by crystallization of the title compound from methanol. Experimental detailsAll of the non-hydrogen atoms were refined anisotropically. The hydrogen atoms were assigned with common isotropic displacement factors U iso (H) = 1.2U eq (N and pyridine C), or U iso (H) = 1.5U eq (methyl C) and included in the final refinement by using geometrical restraints, with C-H = 0.93 Å (pyridine) or C-H = 0.96 Å (methyl), and N-H = 0.86 Å. 12]. In this paper we report the synthesis and crystal structure of a novel thiazolehyrazone compound. The asymmetric unit contains one molecule of the title compound, which is constructed by the pyridinethiazole moiety, the hydrazone linker, and the bimethyl moiety. Discussion

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess awide range of exercise physiology and pharmaceutical activities sucha sf atigue resistance,a nticonvulsant, antioxidant, antimicrobial, antifungal, anticancer, antitubercular ,antiviral, and antibacterial activities [1][2][3][4][5][6][7][8][9].Meanwhile, hydrazones have also interesting ligation properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [10]. The asymmetric unit of the title structure contains two molecules, which are constructed by the pyridinedihydrothiazole moiety, the hydrazone linker, and the biarylmoiety.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of N-cyclopentylidene-N'-thiazolo[4,5-b]pyridin-2-ylhydrazine, C11H12N4S

Zhao

Zhu

2014

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThetitle compound was obtained from 2-amino-3-chloropyridine according to the literature [12]. Single crystals suitable for X-ray diffraction were obtained by crystallization from methanol. Experimental detailsThe hydrogen atomswere assigned with commonisotropic displacementfactors U iso (H) =1.2 times U eq (C,N), and included in the final refinement by using geometrical restraints, with C-H = 0.93Å and N-H =0.86 Å. DiscussionHydrazones are an emerging class of materials, which have been demonstrated to possess awide range of exercise physiology and pharmaceutical activities sucha sf atigue resistance,a nticonvulsant, antioxidant, antimicrobial, antifungal, anticancer, antitubercular ,antiviral, and antibacterial activities [1][2][3][4][5][6][7][8][9].Meanwhile, hydrazones have also interesting ligation properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [10]. The asymmetric unit of the title structure contains two molecules, which are constructed by the pyridinedihydrothiazole moiety, the hydrazone linker, and the biarylmoiety. The C6-N3 and C7-N4 bond length of 1.345(4) Åa nd 1.269(5) Å, conform to the value for adouble bond, while the C6-N2 bond length of 1.299(4) Åconforms to the value for asingle bond. The C2-S1 and C6-S1 bond lengths of 1.735 (4)

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Synthesis of new acridines and hydrazones derived from cyclic β-diketone for cytotoxic and antiviral evaluation

Cited by 101 publications

References 19 publications

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Crystal structure of N-cyclopentylidene-N'-thiazolo[4,5-b]pyridin-2-ylhydrazine, C11H12N4S

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