Synthesis of New Benzo[h]‐ and Benzo[f]chromeno[2,3‐b]‐pyridine‐5‐ones.

Abstract

chromeno[2,3-b]-pyridine-5-ones. -A variety of new derivatives of the title benzochromenopyridine systems is synthesized. The reaction proceeds via condensation of the corresponding benzochromenecarbonitriles (I) with enamines or o-aminobenzochromenecarbaldehydes (VIII) with active methylene compounds. -(ABDEL-RAHMAN*, A.-R. H.; GIRGES, M. M.; EL-AHL, A.-A. S.; SALLAM, L. M.; Heteroat. Chem. 17 (2006) 1, 2-7; Dep. Chem., Fac. Sci., Mansoura Univ., Mansoura 35516, Egypt; Eng.) -M. Kowall 23-157

Acid-Mediated Synthesis of Chromeno[2,3-b]pyridine Derivatives via Condensation of 2-Amino-3-formylchromones and 1-(Methylthio)-2-nitroenamine Derivatives

“…For example, Kumar et al reported an efficient method for the formation of fused chromeno[2,3- b ]pyridine derivatives under mild conditions via Au(III)-catalyzed aldol reaction (Scheme 1a ); 10 Abdel-Rahman et al reported the synthesis of benzochromeno[2,3- b ]-pyridine derivatives from amino-benzochromone-carbaldehydes and ethyl cyanoacetate in 2006 (Scheme 1b ); 11 Ibrahim synthesized chromeno[2,3- b ]pyridines via the Friedländer reactions of 8-allyl-2-amino-4-oxo-4 H -chromene-3-carboxaldehyde with some carbonyl compounds containing a reactive α-methyl or methylene group in 2010 (Scheme 1c ). 12 Although various synthesis methods for certain substrates have been widely covered in literature, more convenient and effective approaches for the synthesis of chromeno[2,3- b ]pyridine derivatives need to be developed.…”

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

“…In the last few years, 1,2,4‐triazole derivatives have attracted the attention of many scientists in agricultural and medicinal fields because of their interesting structural features and biological activities . These derivatives have diverse biological properties, which include anticancer, antitumor, antimicrobial, anti‐inflammatory, antibacterial, antimalarial, antifungal, antiviral, antiproliferative, neuroprotective, pesticidal, herbicidal, antioxidant, anti‐HIV, analgesic, molluscicidal, and anticonvulsant effects …”

Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

“…A large number of thiazole-containing derivatives have been reported to have a wide variety of biological activities, such as antibacterial, antifungal, antitubercular, anti-mycobacterial, anticancer and antiviral. [1][2][3][4][5][6] 2-Amino-thiazol acetate esters are present in most organic compounds of interest in biology, pharmacology, and material sciences. 7 Similarly, 1,3,4-oxadiazoles have had appealing attention for the last two decades due to their extensive range of biological activities, such as anti-inflammatory, antifungal, antiparasitic and antimicrobial effects.…”