Synthesis of New Deoxycholic Acid bis Thiocarbazones under Solvent-Free Conditions using Microwave Irradiation

Abstract

A simple method for the synthesis of new deoxycholic acid bis thiocarbazones under solvent-free conditions using microwave irradiation has been developed. Its main advantages are short reaction times, good conversions and the environmentally friendly nature of the process. Their structures were characterised by 1 H NMR, IR, ESI-MS spectra and elemental analysis. The preliminary results indicate that some of these compounds possess inhibitory effects against Escherichia coli.

Microwave-Assisted Synthesis and Antibacterial Activity of Unsymmetrical Indolyl/Aryl Bis-Thiosemicarbazones

“…In the first step, an aromatic aldehyde 1 is condensed with thiocarbohydrazide in EtOH-H 2 O to yield an aromatic aldehyde semithiocarbohydrazone 2, as previously described. 23,[25][26] In the second step, 2 is reacted with indole-3-carboxaldehyde 3 in acetic acid, either at 80 °C or under MWI, to give the indolyl/ aryl bis-thiosemicarbazones 4.…”

“…21 We have already synthesised a sequence of compounds containing Schiff-base structure using MWI. [22][23][24] The targets underwent antibacterial activity tests and mostly exhibited promising results, leading to a promising theoretical basis for indole-3-carboxaldehyde unsymmetrical bis-thiosemicarbazone synthesis. * Correspondent.…”

(Substituted Ylidene)Amino‐2‐Oxo‐Indolylidene Thioureas and Bis(2‐Oxo‐Indolylidene)Urea from (Ylidene)Thiocarbonohydrazides and Isatylidene Malononitrile

“…3‐(Dicyanomethylene)‐2‐indolone or isatylidene malononitrile 2 was prepared according to Fatiadi . Substituted (hydrazinecarbonothioyl)hydrazinecarbothioamides 4a , 4b , 4c , 4d , 4f , 4g , 4h , 4i , 4j were prepared according to the literature: 4a , 4b , 4c , 4d , 4f , 4g , 4h , 4i , and 4j .…”

Microwave-assisted synthesis of a novel steroid-derived Schiff base chemosensor for detection of Al3+ in aqueous media

“…Besides, steroids are rarely used as a skeleton for fluorescent sensor. In previous studies, [24][25][26][27] we reported a microwave mediated, efficient, high yield, and environmentally friendly synthesis of Schiff base derivatives. Herein, a novel steroidal Schiff base fluorescent sensor, N′-(2-hydroxybenzylidene)-3α-hydroxycholanhydrazide (LA), was designed and prepared via microwave irradiation (Scheme 1), and Al 3+ detection capability of LA has been investigated.…”