Synthesis of new derivatives of Alkylselanyl[1,2,4]triazolo[4,3‐a]pyrimidine asselenium‐containingheterocyclic system

Abstract

We report a facile method to synthesize novel alkyl selanyl [1,2,4]triazolo [4,3-a]pyrimidine heterocyclic scaffolds. A diverse library of selenide derivatives has been prepared via the treatment of 5-bromo-2,4-dichloro-6-methylpyrimidine with potassium selenocyanate as the source of selenium.The selenocyanate anion as the nucleophile is applied to produce 5-bromo-2-chloro-4-methyl-6-selenocyanatopyrimidine (2). The interaction of compound (2) with various alkyl halides afforded alkyl selanyl pyrimidine (3a-e).