Synthesis of new drug model has an effective antimicrobial and antitumors by combination of cephalosporin antibiotic drug with silver(I) ion in nano scale range: Chemical, physical and biological studies

Refat, Moamen S.; Sharshar, T.; Elsabawy, Khaled M.; El‐Sayed, Mohamed Y.; Adam, Abdel Majid A.

doi:10.1016/j.molliq.2017.09.005

Cited by 9 publications

(4 citation statements)

References 55 publications

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“…Indeed, gentamycin plus Ag-NPs in several studies demonstrated enhanced or even synergistic antibacterial effect against (Barapatre, et al 2016;Chhibber, et al 2017;Ebrahimi, et al 2017;Jamaran and Zarif 2016;Katva, et al 2017;Mohamed, et al 2017;Panacek, et al 2015;Satapathy, et al 2017;Verma, et al 2017;Wang, et al 2016).Moreover, in a good agreement with reported data in the literature, penicillin (Ebrahimi, et al 2017;Panacek, et al 2015) in contrary to some studies (Deng, et al 2016;Natan and Banin 2017;Wang, et al 2016) and ciprofloxacin in the case of human strains (Mohamed, et al 2017;Yallappa, et al 2015) in accord with our data (Panacek, et al 2015) showed significant increase in antibacterial activities when conjugated with Ag-NPs. Furthermore, tetracycline (Deng, et al 2016;Ebrahimi, et al 2017;Natan and Banin 2017), amoxicillin (Mohamed, et al 2017), cephalosporin (Refat, et al 2017), erythromycin (Yallappa, et al 2015 showed partially increase in antibacterial activities in the presence of Ag-NPs. On the other hand, to the contrary to our study, ampicillin (Satapathy, et al 2017), nalidixic acid (Tawfeeq, et al 2017) have been mentioned to have a synergistic effect.…”

Section: Discussionmentioning

confidence: 99%

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Kazemnia

Ahmadi

Mardani

et al. 2019

J Hellenic Vet Med Soc

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Silver nanoparticles (Ag-NPs) can attach to flexible polymeric chains of antibiotics, hence it can be used in combination with antibiotics against resistant bacteria. In this study, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and MBC/MIC ratio of Ag-NPs and antibiotics (gentamicin, tetracycline, erythromycin, ciprofloxacin, nalidixic acid, cefixime, cephalexin, amoxicillin, ampicillin, and penicillin) were quantified against 50 Escherichia coli isolates (25 human urinary tract infection and 25 avian colibacillosis). All isolates had been assigned as four phylogenetic groups A, B1, B2, and D. The results showed that the majority of the human and broiler isolates belonged to phylogenetic groups A and B2. MBC/MIC ratio of Ag-NPs in combination with antibiotics was assessed. It was found that the MIC of the majority of broiler isolates to Ag-NPs was equal to or greater than 50 μg/ml. To conclude, a combination of penicillin and ciprofloxacin with Ag-NPs exhibited profound impact against isolates, the combinations might be applicable for treating multidrug-resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Kazemnia

Ahmadi

Mardani

et al. 2019

J Hellenic Vet Med Soc

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“…The energy of HOMO orbital shows its ability to lose electrons; thus, the ionization potential is connected with it, while the electronic affinity links to the energy of the LUMO orbital, which shows the ability to accept electrons [46][47][48] . Meanwhile, the difference between the two molecular orbitals, the "energy gap", measures the reactivity of the molecule; the larger the energy gap, the lower the reactivity and polarizability of the compound 49,50 .…”

Section: Frontier Molecular Orbitalmentioning

confidence: 99%

New inorganic inhibitors derived from cefotaxime to enhance corrosion resistance of mild steel in 3% NaCl

Abd El-Zahir,

Soliman,

ELKady

et al. 2024

Sci Rep

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To overcome the threat of corrosion and its cost, a new Schiff base was prepared and utilized to synthesize inorganic inhibitors to enhance corrosion resistance and reduce current density. The Schiff base was obtained from the interaction of cefotaxime with acetylacetone, while 1H NMR and IR spectra were used to confirm the preparation. Moreover, FeIII, CoII, NiII and CuII metal salts were reacted with the Schiff base to give the corresponding complexes. Meanwhile, the non-ionic behavior of the observed complexes in solutions was proved from the conductance results. In addition, the octahedral geometry and the postulated structure of complexes were determined from CHNM%, IR spectroscopy, UV-visible spectra, and TGA analysis. Also, the energy of molecular orbitals (HOMO and LUMO) and other quantum mechanics parameters were calculated using the DFT method. The observed results indicated the reactivity of metal complexes and their ability to donate electrons more than the Schiff base. Furthermore, the corrosion rate of a steel sample under various concentrations of inhibitors was calculated by a potentiodynamic polarization test. The obtained data displayed that metal complexes declined the corrosion rate more than the Schiff base; therefore, the binding between the metal ion and the Schiff base improved the inhibition efficiency.

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“…The vital role of inorganic salts in living systems can be revealed by studying biological and biochemical systems. The chemistry of inorganic compounds is not the "dead chemistry" that lot of people may imagine [1][2][3]. Presently, metal ions are as important components of life as organic compounds.…”

Section: Introductionmentioning

confidence: 99%

“…For many diseases, minerals are also used as inorganic medicines. However, the focus in this article is on of metal molecule interactions, as well as the chemistry and structure of metal complexes [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

El‐Megharbel

Refat

Al-Salmi

et al. 2021

IJERPH

Self Cite

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Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2O, and [Se(STG)2(Cl)2]Cl2, respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg2+, Ca2+, Cr3+, Zn2+, Cu2+, and Se4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone.

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Synthesis of new drug model has an effective antimicrobial and antitumors by combination of cephalosporin antibiotic drug with silver(I) ion in nano scale range: Chemical, physical and biological studies

Cited by 9 publications

References 55 publications

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

New inorganic inhibitors derived from cefotaxime to enhance corrosion resistance of mild steel in 3% NaCl

In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

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