Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

Sato, Kazuyuki; Kawasaki, Akira; Karuo, Yukiko; Tarui, Atsushi; Kawai, Kentaro; Omote, Masaaki

doi:10.3762/bjoc.16.117

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…In drug delivery, small-sized lipid nanoparticles (LNPs) have potential, but their poor stability and intracellular trafficking weaken their effectiveness. The potential of creating hydrophobic scaffolds can be increased by using transformed, self-assembled LNP containing lipids and proteins that have been previously used for gene or drug delivery [ 173 ]. The choice of scaffold depends on the specific biological application and intended usage, which can range from biotechnology to regenerative medicine for organ regeneration.…”

Section: Biomimetic Scaffolds—from Advanced Engineering To Biological...mentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding. Scaffold-free techniques consist of spheroid technologies. Meanwhile, scaffold techniques contain organoids and all constructs that use various types of scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels that are one of the most extensively studied forms of potential scaffolds for 3D culture up to 4D bioprinted biomaterials. 3D bioprinting is one of the most important techniques used to create biomimetic scaffolds. The versatility of this technique allows the use of many different types of inks, mainly hydrogels, as well as cells and inorganic substances. Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. Recent papers also indicate increasing amounts of in vivo tests of products based on biomimetic scaffolds, which further strengthen the importance of this branch of tissue engineering and emphasize the need for extensive research to provide safe for humansbiomimetic tissues and organs. In this review article, we provide a review of the recent advancements in the field of biomimetic scaffolds preceded by an overview of cell culture technologies that led to the development of biomimetic scaffold techniques as the most complex type of cell culture.

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Section: Biomimetic Scaffolds—from Advanced Engineering To Biological...mentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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“…Hence, there is an urgent need to design ultrasensitive strategies to improve detection performance. Various strategies have been employed to solve these problems, including the synthesis of new fluorescent substances, the improvement of instruments for fluorescence detection, and the establishment of an integrated analysis system [ 12 , 13 , 14 ]. Recently, the use of functionalized nanomaterials in fluorescence detection techniques has provided a new opportunity for the selective and ultrasensitive detection and quantification of biomarkers.…”

Section: Introductionmentioning

confidence: 99%

The Fluorescence Detection of Phenolic Compounds in Plicosepalus curviflorus Extract Using Biosynthesized ZnO Nanoparticles and Their Biomedical Potential

Amina

Musayeib

Alarfaj

et al. 2022

Plants

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A facile, eco-friendly fluorescence approach based on the biogenic formation of zinc oxide nanoparticles using the biomass of Plicosepalus curviflorus shoots was developed. The suggested approach was employed to analyze three phenolic compounds (catechin, curviflorside, and curviflorin) isolated from the shoots of P. curviflorus. The surface morphology of the prepared ZnONPs was characterized by carrying out different microscopic and spectroscopic investigations. A significant UV-Vis absorption peak of ZnONPs was recognized at 345 nm and the FT-IR spectra of the isolated catechin, curviflorside, and curviflorin in the presence of sodium dodecyl sulfate (SDS) and ZnONPs were recorded at λem 470, 490, and 484 nm after excitation at λex 380, 420, and 410 nm. The suggested fluorescence method displayed linear concentration ranges of 10–120, 5–100, and 10–150 μg mL−1 for the three isolated compounds, respectively. The shoot extract, isolated compounds, and ZnONPs were screened for antibacterial and anticancer effects against four different types of bacterial strains and HeLa cells, respectively. The ZnONPs exhibited the highest zone of inhibition against Escherichia coli and Staphylococcus aureus strains when compared with pure, isolated compounds and shoot extract. The anticancer potential of ZnONPs (64%) was stronger as compared to the 160 µg mL−1 of shoot extract (49%), catechin (52%), curviflorside (54%), and curviflorin (58%) at 160 µg mL−1. Moreover, all the samples were investigated for hemolysis activity and showed a potent anti-hemolytic effect. The developed analytical method showed excellent sensitivity and reliability for the concurrent analysis of the isolated bioactive markers.

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“…Furthermore, isoxazoles are also found in neuropsychiatric therapy [8] and in crop protection [9]. Surprisingly, their photophysical properties have remained largely unexplored [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Rapid Sequentially Palladium Catalyzed Four-Component Synthesis of Novel Fluorescent Biaryl-Substituted Isoxazoles

et al. 2020

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A series of novel 3- and 5-biaryl-substituted isoxazoles was prepared by a rapid microwave-assisted four-component three-step synthesis: concatenating Sonogashira coupling, cyclocondensation, and Suzuki coupling in a one-pot fashion. The Pd-catalyst was successfully employed in the sense of a sequentially catalyzed process, i.e., without the addition of further catalyst loading. Biaryl-substituted isoxazoles with donor–acceptor decoration possess remarkable photophysical properties, such as high fluorescence quantum yields in solution up to ΦF = 0.86 and large Stokes shifts up to 10,000 cm−1. The experimental absorption and emission characteristics can be reproduced and rationalized by computations on the DFT (density functional theory) and TDDFT (time-dependent density functional theory) level of theory.

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Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

Cited by 8 publications

References 39 publications

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

The Fluorescence Detection of Phenolic Compounds in Plicosepalus curviflorus Extract Using Biosynthesized ZnO Nanoparticles and Their Biomedical Potential

Rapid Sequentially Palladium Catalyzed Four-Component Synthesis of Novel Fluorescent Biaryl-Substituted Isoxazoles

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