Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

Abstract

Fluorescent molecules based on a fluorinated isoxazole scaffold were provided for the synthetic methods and their photochemical properties. Simple 3,5-diarylisoxazoles led to increasing the fluorescent intensity and exhibited a redshift in the emission intensity by introducing a fluorine atom. α-Fluorinated boron ketoiminates (F-BKIs) derived from a ring opening reaction of 4-fluoroisoxazoles were also synthesized and exhibited a highly fluorescent luminescence as a new aggregation-induced emission (AIE) fluorophore.

Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems

“…Isoxazoles rarely occur in nature, yet, these heterocycles possess enormous bioactive properties (Palmer and Venkatraman, 2003) and are therefore used in therapeutics (Kumbhare et al, 2012;Joshi et al, 2017;Pairas et al, 2017). However, their photophysical properties are still largely unexplored (Irfan et al, 2016;de Brito et al, 2018;Sato et al, 2020). Some one-pot methods for the formation of isoxazoles have been reported (Merkul and Müller, 2006;Kaim et al, 2009;Wachenfeldt et al, 2013).…”