Synthesis of New Ligands Containing Azomethine Group and Investigation of   Antioxidant,  Antiurease Activities

Gümrükçüoğlu, Nurhan; Sökmen, Bahar Bilgin

doi:10.35378/gujs.615818

Cited by 2 publications

(7 citation statements)

References 35 publications

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“…The dehydration of compound (1) with acetic anhydride was afforded (2). The structure was confirmed by 1 HNMR the two signals at δ 7.99-7.73 ppm multiplit corresponding to pyridine and phenyl protons.…”

Section: -Results and Discussionmentioning

confidence: 84%

“…One of the interesting fields of organic chemist is to prepare new compounds. These compounds could solve one or more problem in different aera scheme (2). In this paper we used to make acetylation reaction of furo [3, 4-b] pyridine-5,7-dione as starting material with aniline as nucleophile to form acetanilide (1)in 80%.…”

Section: -Results and Discussionmentioning

confidence: 99%

“…208-210 ֯ c); IR cm -1 , 3101, 1724, 1620, 1394; 1 HNMR (300 MHz, DMSO -d 6 ) δ 7.99-7.94 (m, 3 H), 7.7-7.73 (m, 5 H). Chlorosulfonic acid (4ml) was added dropwise to (0.01 mole, 2.23 gm) of (2). during two hours with stirring and keeping temp.…”

Section: Synthesis Of 6-phenyl-5h -Pyrrolo [34-b] Pyridine -57(6h)-di...mentioning

confidence: 99%

“…after that, the resulting precipitate filtered, washed with cold ethanol, dried, and recrystallized from suitable solvent. Table (1), show the physical properties, table (2) the IR spectra result and table (3) the HMNR shifts.…”

Section: Synthesis N-arylidene -4-(5 7-dioxo-5 7-dihydro-6h-pyrrolo [...mentioning

confidence: 99%

“…In 2019 Qian Yang [1] has reported a green synthesis using tyrosine as a catalyst (scheme 1). In addition, in the last decade there are several of researchers used to synthesize number of these compounds and other Schiff base for different purposes [2][3][4][5][6]. .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of new N- Aryl sulfonyl hydrazone compounds

Fathi

Mohammed

2021

Egypt. J. Chem.

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In this paper we report synthesis of new substituted benzene sulfonohydrazone by the reaction of aniline with furo [3,4-b] pyridine-5,7-dione to give 2-(phenylcarbamoyl) nicotinic acid (1) which can be convert to 6-phenyl -5H-pyrrolo[3,4b] pyridine -5,7(6H)-dione (2) by its reaction with acetic anhydride in the presence of sodium acetate. This compound was treated with chlorosulfuric acid to give 4-(5,7-dioxo-5,7-dihydro-6H-pyrrolo [3,4-b] pyridine 6-yl) benzenesulfonyl chloride (3). The compound (3) was reacted with hydrazine hydrate to give hydrazone (4). Lastly, the resulted hydrazone (4) was handled with numbers of aromatic aldehydes and ketones to give substituted benzene sulfonohydrazones (5-12).

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Section: -Results and Discussionmentioning

confidence: 84%

Section: -Results and Discussionmentioning

confidence: 99%

Section: Synthesis Of 6-phenyl-5h -Pyrrolo [34-b] Pyridine -57(6h)-di...mentioning

confidence: 99%

Section: Synthesis N-arylidene -4-(5 7-dioxo-5 7-dihydro-6h-pyrrolo [...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of new N- Aryl sulfonyl hydrazone compounds

Fathi

Mohammed

2021

Egypt. J. Chem.

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Investigation of the Effect of Compound B-47/2 Containing Azomethine Group on Angiogenesis

BUCAK

Tuncbilek

Huseynzada

et al. 2022

CMJ

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Objective: Lung cancer is one of the most common cancers in the world. It is known that angiogenesis plays a role in the development and metastasis of lung cancer. The anticancer properties of azomethine derivatives known as Schiff bases have been demonstrated. In this study, we aimed to determine the anticancer activity of the newly synthesized azomethine derivative compound B-47/2 on lung cancer and to determine the effect of this component on VEGFB gene expression. Material and Method: Compound B-47/2 was synthesized for the first time. B-47/2 compound was applied to lung cancer cell line A549 at varying concentrations (1-100 µg/mL) and its anticancer activity was found after 24, 48 and 72 incubations using the MTT method. The IC50 dose of B-47/2 was applied to the cells and RNA isolation followed by cDNA synthesis was performed. Then, RT-PCR method was used to determine the expression level of VEGF gene. Results: As a result, it was determined that the B-47/2 compound applied to the A-549 cell line showed the highest cytotoxic activity after 72 hours of incubation. In addition, it was determined that the B-47/2 compound decreased the expression of the VEGFB gene. Discussion: There are studies in which the anticancer activity of azomethine derivatives has been observed. The topic of synthesizing new drugs to prevent cancer is popular. We suggested that the newly synthesized component may have anticancer activity and may be effective on angiogenesis.

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Synthesis of New Ligands Containing Azomethine Group and Investigation of Antioxidant, Antiurease Activities

Abstract: Highlights• As standard antioxidant, Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) was used.• The reducing power activities of the compounds were compared with BHT.• Values were the means of three replicates ± Standard deviation .

Cited by 2 publications

References 35 publications

Synthesis and characterization of new N- Aryl sulfonyl hydrazone compounds

Synthesis and characterization of new N- Aryl sulfonyl hydrazone compounds

Investigation of the Effect of Compound B-47/2 Containing Azomethine Group on Angiogenesis

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