Synthesis of new methoxy derivatives of trans 2,3-diaryl-2,3-dihydrobenzofurans and evaluation of their anti-inflammatory activity

Laurita, Teresa; Pappalardo, Ilaria; Chiummiento, Lucia; D’Orsi, Rosarita; Funicello, Maria; Santarsiero, Anna; Marsico, Michela; Infantino, Vittoria; Todisco, Simona; Lupattelli, Paolo

doi:10.1016/j.bmcl.2021.128264

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Human monoblasticleukemia U937 cell line (Interlab Cell Line Collection (ICLC) HTL94002) was grown in suspension in Roswell Park Memorial Institute (RPMI) 1640 medium (Sigma, Milan, Italy) supplemented with 10% (v/v) fetal bovine serum, 2 mM L-glutamine, 100 U/mL penicillin, and 100 µg/mL streptomycin at 37 • C in 5% CO 2 as previously reported [56]. U937 cell were seeded in RPMI (CTRL) or in RPMI where the four strains were grown for 24 h. Pro-monocytic U937 cells were differentiated to macrophages by 10 ng/mL phorbol 12-myristate 13-acetate (PMA).…”

Section: Cell Culture and Treatmentsmentioning

confidence: 99%

In Vitro Study of Probiotic, Antioxidant and Anti-Inflammatory Activities among Indigenous Saccharomyces cerevisiae Strains

Siesto

Pietrafesa

Infantino

et al. 2022

Foods

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Nowadays, the interest toward products containing probiotics is growing due to their potential health benefits to the host and the research is focusing on search of new probiotic microorganisms. The present work was focused on the characterization of indigenous Saccharomyces cerevisiae strains, isolated from different food matrixes, with the goal to select strains with probiotic or health-beneficial potential. A preliminary screening performed on fifty S. cerevisiae indigenous strains, in comparison to a commercial probiotic strain, allowed to individuate the most suitable ones for potential probiotic aptitude. Fourteen selected strains were tested for survival ability in the gastrointestinal tract and finally, the strains characterized for the most important probiotic features were analyzed for health-beneficial traits, such as the content of glucan, antioxidant and potential anti-inflammatory activities. Three strains, 4LBI-3, LL-1, TA4-10, showing better attributes compared to the commercial probiotic S.cerevisiae var. boulardii strain, were characterized by interesting health-beneficial traits, such as high content of glucan, high antioxidant and potential anti-inflammatory activities. Our results suggest that some of the tested S. cerevisiae strains have potential as probiotics and candidate for different applications, such as dietary supplements, and starter for the production of functional foods or as probiotic to be used therapeutically.

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Section: Cell Culture and Treatmentsmentioning

confidence: 99%

In Vitro Study of Probiotic, Antioxidant and Anti-Inflammatory Activities among Indigenous Saccharomyces cerevisiae Strains

Siesto

Pietrafesa

Infantino

et al. 2022

Foods

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show abstract

“…In fact, citrate contributes to the synthesis of chemical mediators of inflammation, namely ROS, nitric oxide (NO), and prostaglandin E 2 (PGE 2 ), and can affect cytokine secretion [ 32 , 33 , 34 ]. The inhibition of the citrate pathway, composed of citrate, mitochondrial citrate carrier and ATP citrate lyase (ACLY), by synthetic [ 35 , 36 ] and natural compounds, such as hydroxycitric acid (HCA) [ 18 , 34 , 37 ], counteracts inflammation and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Exploiting the Anti-Inflammatory Potential of White Capsicum Extract by the Nanoformulation in Phospholipid Vesicles

et al. 2021

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The peppers of the Capsicum species are exploited in many fields, as flavoring agents in food industry, or as decorative and therapeutic plants. Peppers show a diversified phytochemical content responsible for different biological activities. Synergic activity exerted by high levels of antioxidant compounds is responsible for their important anti-inflammatory property. A methanolic extract was obtained from a new pepper genotype and tested for anti-inflammatory activity. The extract was incorporated into phospholipid vesicles to increase the bioavailability of its bioactive components. Two types of phospholipid vesicles were produced, conventional liposomes and Penetration Enhancer containing Vesicles (PEVs). They were tested in human monoblastic leukemia U937 cell line, showing no cytotoxic effect. The intracellular reactive oxygen species (ROS) and nitric oxide (NO) levels were measured to value the in vitro efficacy of the vesicles in regulating inflammatory responses. Liposomal incorporation significantly reduced ROS levels in extract-treated LPS-activated cells. Furthermore, LC-MS/MS analyses demonstrated that liposomes facilitated the transport of the extract components across the cell membrane and their accumulation into the cytoplasm.

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Additive‐Free and Diastereoselective Synthesis for Trans‐Disubstituted‐2,3‐Dihydro‐Benzofurans via [4+1] Annulation between p‐QMs and TFISYs

Li,

Wang,

Ren

et al. 2024

Eur J Org Chem

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Synthesis of new methoxy derivatives of trans 2,3-diaryl-2,3-dihydrobenzofurans and evaluation of their anti-inflammatory activity

Cited by 3 publications

References 32 publications

In Vitro Study of Probiotic, Antioxidant and Anti-Inflammatory Activities among Indigenous Saccharomyces cerevisiae Strains

In Vitro Study of Probiotic, Antioxidant and Anti-Inflammatory Activities among Indigenous Saccharomyces cerevisiae Strains

Exploiting the Anti-Inflammatory Potential of White Capsicum Extract by the Nanoformulation in Phospholipid Vesicles

Additive‐Free and Diastereoselective Synthesis for Trans‐Disubstituted‐2,3‐Dihydro‐Benzofurans via [4+1] Annulation between p‐QMs and TFISYs

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