Synthesis of new organophosphorus‐substituted derivatives of functionalized propionates and their analogues

1‐Heteroakylation of tris(trimethylsilyl)phosphine

“…The proposed scheme was confirmed by observing that Lewis acids facilitate the cleavage of the P Si bond [10] and the generation of carbonioimmonium ions [11][12][13]. In contrast, phosphine 1 reacted exothermically with N-methoxymethyl dialkylamines in the presence of methanol as a catalyst, and this reaction was easily completed under heating at 60…”

Synthesis of new types of N,N‐disubstituted aminomethylspirophosphoranes

“…These heterosubstituted methylamines A were used as aminomethylating reagents because of their possibilities to generate highly reactive electrophilic carboimmonium ions B (cf. [8][9][10][11]; (Eq. 1).…”

Synthesis of new functionalized mono‐ and bisorganophosphorus acids and their derivatives with unsaturated and aromatic fragments

“…[5,12]). As initial compounds, we used accessible trimethylsilyl phosphites and 2-pyridylethylphosphonite that were successfully applied earlier to the synthesis of organophosphorus analogs of amino acids containing amino and carboxyl groups [13]. Therefore, trimethylsilyl phosphites and bis(trimethylsilyl) 2-pyridylethylphosphonite readily react with acid chlorides in methylene chloride to form bisphosphonate 14-18 or bisphosphinates 19-22, respectively, in high yields (Eq.…”