Synthesis of new pentaheterocyclic ring system as antiandrogene, anti HCV and anti H1N1 agents

Farghaly, Thoraya A.; Abbas, I. M.; Abdalla, Mohamed M.; Mahgoub, Raghda O. A.

doi:10.3998/ark.5550190.0013.606

Cited by 12 publications

(1 citation statement)

References 11 publications

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“…Enaminoketoesters have gained a lot of attention in recent years due to its use as a building block precursor in the synthesis of several different organic compounds including enaminone [1] isoxazole, [2] pyrazole, [3] α-pyridone, [4] γ-pyridone, [5] pyrimidine [6] and fused tetracyclic compounds. [7] Enaminoketoesters are not only used in general applications but also play a key role in the synthesis of FDA-approved drugs such as dolutegravir, cabotegravir, and bictegravir (Figure 1). [8] Based on this, people have been curious about how enaminoketoester and its derivatives are synthesized for a long time.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Assisted Zinc‐Catalyzed One‐pot Synthesis of Enaminoketoesters

et al. 2023

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Herein we report an ultrasound‐assisted zinc‐catalyzed solvent‐free process for the synthesis of enaminoketoesters from 1,3 dicarbonyl compounds, N, N‐Dimethylformamide dimethyl acetal (DMFDMA) and various amines with good to excellent yields. This methodology is very much applicable for primary aliphatic, aromatic and secondary alicyclic amines bearing different functional groups. The present work offers the following merits such as inexpensive reagents, one‐pot reaction, eco‐friendly and tolerance to different functional groups with short reaction time.

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Section: Introductionmentioning

confidence: 99%

Ultrasound‐Assisted Zinc‐Catalyzed One‐pot Synthesis of Enaminoketoesters

et al. 2023

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Antimicrobial Activity of Novel Tetra‐ and Penta‐azaheterocyclic Ring Systems

Gomha

Abbas

Farghaly

2016

Journal of Heterocyclic Chem

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A novel series of substituted [1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5‐c]benzo[f]isoquinolin‐14(10H)‐one was synthesized from the reaction of hydrazonoyl chlorides with pyrimidine thione derivative or via oxidative cyclization of 3‐(2‐substituted‐benzylidene‐hydrazinyl)‐7,8‐dihydrobenzo[f]pyrimido[4,5‐c]isoquinolin‐1(2H)‐one. Also, some polyhetero‐cyclic ring systems were prepared through the reaction of 2‐dimethylaminomethylene‐3,4‐dihydro‐2H‐naphthalen‐1‐one and heterocyclic amines. The biological activity of some new products was evaluated, and the results obtained revealed that compounds 10e, 13a, and 18 showed excellent activities against the most bacteria and fungi species used.

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Synthesis and Reactions of Pyrido[2,1‐a]isoquinolin‐4‐yl Formimidate Derivatives and Antimicrobial Activities of Isolated Products

Hassaneen

Wardakhan

Mohammed

2017

Journal of Heterocyclic Chem

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Treatment of arylidene malononitriles 2A–C with 1‐cyanomethylisoquinoline 1 afforded 4‐amino‐2‐arylpyrido[2,1‐a]isoquinoline‐1,3‐dicarbonitrile derivatives 5A–C, which converted to formimidates 6A–C via reaction with triethylorthoformate. Treatment of the latter compounds with hydrazine hydrate gave the corresponding amino–imino compounds 7A–C, which underwent Dimroth rearrangement to afford 13‐aryl‐1‐hydrazinylpyrimido[5′,4′:5,6]pyrido[2,1‐a]isoquinoline‐12‐carbonitrile 8A–C. The latter reacted with aldehyde to give 9a–i. Oxidative cyclization of the latter compounds 9a–i gave [1,2,4]triazolo[4″,3″:1′,6′]‐pyrimido[5′,4′:5,6]pyrido[2,1‐a]isoquinolines 10a,d,g. Such compounds isomerized to the thermodynamically more stable isomers [1,2,4]triazolo[1″,5″:1′,6′]pyrimido[5′,4′:5,6]‐pyrido[2,1‐a]isoquinolines 11a,d,g. Antimicrobial activities for some compounds were studied.

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Synthesis of new pentaheterocyclic ring system as antiandrogene, anti HCV and anti H1N1 agents

Abstract: A new series of pentaheterocycles, namely, benzo [5',6']pyrano[4',3':4,5]pyrido [2,3-d]triazolo [4,3-a]

Cited by 12 publications

References 11 publications

Ultrasound‐Assisted Zinc‐Catalyzed One‐pot Synthesis of Enaminoketoesters

Ultrasound‐Assisted Zinc‐Catalyzed One‐pot Synthesis of Enaminoketoesters

Antimicrobial Activity of Novel Tetra‐ and Penta‐azaheterocyclic Ring Systems

Synthesis and Reactions of Pyrido[2,1‐a]isoquinolin‐4‐yl Formimidate Derivatives and Antimicrobial Activities of Isolated Products

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