Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies

Ain, Qurat Ul; Saeed, Aamer; Khan, Ajmal; Ahmed, Atteeque; Ullah, Saeed; Halim, Sobia Ahsan; Irfan, M. Nurul; Tehzeeb, Arfa; El‐Seedi, Hesham R.; Muhsinah, Abdullatif Bin; Al‐Harrasi, Ahmed

doi:10.1016/j.bioorg.2022.106302

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…The coumarin based azomethine-clubbed thiazoles synthesis was documented by Al-Harrasi and co-workers in (Ul Ain et al, 2023. The authors evaluated the in vitro activity of the obtained compounds against α-glucosidase for the plausible treatment of diabetes mellitus (T2DM).…”

Section: Anti-diabetesmentioning

confidence: 99%

Syntheses, reactivity, and biological applications of coumarins

Citarella,

Vittorio,

Dank

et al. 2024

Front. Chem.

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This comprehensive review, covering 2021–2023, explores the multifaceted chemical and pharmacological potential of coumarins, emphasizing their significance as versatile natural derivatives in medicinal chemistry. The synthesis and functionalization of coumarins have advanced with innovative strategies. This enabled the incorporation of diverse functional fragments or the construction of supplementary cyclic architectures, thereby the biological and physico-chemical properties of the compounds obtained were enhanced. The unique chemical structure of coumarine facilitates binding to various targets through hydrophobic interactions pi-stacking, hydrogen bonding, and dipole-dipole interactions. Therefore, this important scaffold exhibits promising applications in uncountable fields of medicinal chemistry (e.g., neurodegenerative diseases, cancer, inflammation).

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Section: Anti-diabetesmentioning

confidence: 99%

Syntheses, reactivity, and biological applications of coumarins

Citarella,

Vittorio,

Dank

et al. 2024

Front. Chem.

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“…The a-glucosidase inhibition assay was performed by using our previous reported methodology. [47][48][49] Experiments were carried out by using phosphate buffer 50 mM, pH. 6.8.…”

Section: A-glucosidase Inhibition Assay and Statistical Analysismentioning

confidence: 99%

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies

Tariq,

Saeed,

Ullah

et al. 2023

RSC Adv.

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“… 5 Numerous scientists in the area of medicinal chemistry have performed extensive studies on pyrazoline scaffolds for curing a range of diseases. 6 Pyrazolines possess diverse biological activities, including anti-cancer, 7 anti-Alzheimer, 8 anti-tuberculosis, 9 anti-inflammatory, 10 antimicrobial, 11 anti-EGFR 12 and anti-Parkinsonian. 13 The pyrazoline ring system is an important structural property of numerous drugs used in clinical trials to treat various disorders.…”

Section: Introductionmentioning

confidence: 99%