Synthesis of New Pyrazole Derivatives Containing 2-Methylquinoline Ring System: A Novel Class of Potential Antimicrobial Agents

Abstract

Two series of diversely substituted 1-(3,5-dimethyl-4-(substitutedphenyldiazenyl)-1Hpyrazol-1-yl)-2-((2-methylquinolin-8-yl)oxy)ethanones (8a-g) and 3-methyl-1-(2-((2-methylquinolin-8-yl)oxy)acetyl)-4-(2-substitutedphenylhydrazono)-1H-pyrazol-5(4H)-ones (9a-h) were synthesized. All the newly synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, Mass and chemical analysis. The compounds were evaluated for their in vitro antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and screened for antifungal activity against Aspergillus niger, Ustilago maydis using the agar disc diffusion method. All the tested compounds showed significant antibacterial activity against both the strains with compounds 8d and 9d being more potent.

Cyanoquinolines and Furo[3,4-b]quinolinones Formation via On-The-Spot 2,3-Functionalization of Quinolines with Cyanopropargylic Alcohols

“…Functionalized quinolines are the object of intensive research owing to their biological activity. These compounds exhibit anticancer, antitubercular, antibacterial, antioxidant, antifungal, and antiviral activities. Of special interest are cyano-substituted quinolines.…”