Synthesis of new pyrazolyl-1,3-diazabicyclo[3.1.0]hexe-3-ene derivatives

Synthesis of chromenone, pyrimidinone, thiazoline, and quinolone derivatives as prospective antitumor agents

“…Condensation of 1‐phenyl‐3‐(thiophen‐2‐yl)‐pyrazole‐4‐carboxaldehyde (1) with 2‐cyanoacetohydrazide 2 in refluxing ethanol for 2 hours afforded the corresponding N ‐condensation product (3) in a good yield as yellow crystals (Scheme ). Knoevenagel condensation of the active methylene compound 3 with aromatic aldehydes namely, 2,4‐dichlorobenzaldehyde and pyrazole aldehyde 1 in dioxane containing piperidine as a base at ambient temperature afforded the α , β ‐unsaturated carbonyl compounds 4a,b , respectively (Scheme ).…”

“…The antitumor activity assay was carried out at Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. The starting aldehyde namely, 1‐phenyl‐3‐(thiophen‐2‐yl)‐1 H ‐pyrazole‐4‐carbaldehyde (1) was previously prepared …”

The Novel Synthesis of Functionalized Indenopyrazolones Using Fe3O4 nanoparticles stabilized on MMT: An Efficient Magnetically Recoverable Heterogeneous Nanocomposite Catalyst

“…Among these compounds that have been the focus of regard for several studies, the core structures of numerous biologically active compounds and the exhibit of numerous applications in chemistry, biology, and other sciences are nitrogen‐containing heterocycles . A famous example of aromatic heterocyclics contains two nitrogen atoms in the five‐membered rings are pyrazoles . Pyrazole derivatives act as monoamine oxidase inhibitors , BRAF inhibitors , DNA gyrase inhibitor , antileishmanial , antiproliferative , anti‐inflammatory , analgesic , and cyclin‐dependent kinase inhibitors (Fig.…”

A concise route for the one-pot multi-component synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles and pyranopyrazoles using cobalt (II) nitrate hexahydrate as catalyst

“…Pyrazole unit is widely prevalent in natural products and bioactive molecules. 11,12 They act as essential structures in the skeletons of numerous commercial drugs (e.g. celecoxib, ENMD-2076, R1530, PNU-32945, rimonabant, metamizole, and sulfaphenazole).…”