Synthesis of New Substituted 2-(Trimethylstannyl)indoles

Kumar, Arvind; Say, Martial; Boykin, David W.

doi:10.1055/s-2008-1032162

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Protection of 5-bromoindole 1 was performed using Boc anhydride in presence of DMAP as a catalyst and DCM as a solvent. The Boc-protected derivative 2 was lithiated using LDA in THF at –20 °C followed by in situ conversion into organometalic stannane 3 using trimethyltin chloride [ 41 , 42 ]. Stille coupling of stannane derivative 3 with 4-bromo-3-methylbenzonitrile employing Pd(PPh 3 ) 4 in dioxane [ 41 ] afforded compound 4 .…”

Section: Resultsmentioning

confidence: 99%

Small Molecules Incorporating Privileged Amidine Moiety as Potential Hits Combating Antibiotic-Resistant Bacteria

et al. 2023

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The continuing need for the discovery of potent antibacterial agents against antibiotic-resistant pathogens is the driving force for many researchers to design and develop such agents. Herein, we report the design, synthesis, and biological evaluation of amidine derivatives as new antibacterial agents. Compound 13d was the most active in this study against a wide range of antibiotic-resistant, and susceptible, Gram-positive, and Gram-negative bacterial strains. Time–kill assay experiments indicated that compound 13d was an effective bactericidal compound against the tested organisms at the log-phase of bacterial growth. Docking simulations were performed to assess in silico its mode of action regarding UPPS, KARI, and DNA as potential bacterial targets. Results unveiled the importance of structural features of compound 13d in its biological activity including central thiophene ring equipped with left and right pyrrolo[2,3-b]pyridine and phenyl moieties and two terminal amidines cyclized into 4,5-dihydro-1H-imidazol-2-yl functionalities. Collectively, compound 13d represents a possible hit for future development of potent antibacterial agents.

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Section: Resultsmentioning

confidence: 99%