2019
DOI: 10.1002/slct.201902774
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Synthesis of New Sulfoximine‐Tethered Alkynones and Further Extension towards Metal‐Free Synthesis of Pyrimidines, Amino Pyrimidines, Pyrazoles and Isoxazoles

Abstract: A metal free and divergent synthetic method has been successfully developed for the synthesis of sulfoximine tethered pyrimidines, amino pyrimidines, pyrazoles and isoxazoles. Two key sulfoximine tethered alkynone intermediates ((tert‐butyldiphenylsilyl)imino)(2‐oxo‐4‐phenylbut‐3‐yn‐1‐yl)(phenyl)‐λ6‐sulfanone (3 a) and ((tert‐butyldiphenylsilyl)imino)(2‐oxopent‐3‐yn‐1‐yl)(phenyl)‐λ6‐sulfanone (3 b), have been reported for the first time and were used as the common building blocks to construct these heterocycle… Show more

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Cited by 4 publications
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“…Now, we have discovered highly selective cyclization reactions of S -methyl derivatives of N -ynonylsulfoximines providing three-dimensional heterocycles 2 under very mild reaction conditions (Scheme ). In this Letter, we summarize the initial observations and subsequent optimization studies.…”
mentioning
confidence: 99%
“…Now, we have discovered highly selective cyclization reactions of S -methyl derivatives of N -ynonylsulfoximines providing three-dimensional heterocycles 2 under very mild reaction conditions (Scheme ). In this Letter, we summarize the initial observations and subsequent optimization studies.…”
mentioning
confidence: 99%