Synthesis of New Zirconium Magnetic Nanocomposite as a Bioactive Agent and Green Catalyst in the Four-Component Synthesis of a Novel Multi-Ring Compound Containing Pyrazole Derivatives

Asiri, Mohammed; Abdulsalam, Ahmed Ghalib; Kahtan, Mustafa; Alsaikhan, Fahad; Farhan, Issa; Mutlak, Dhameer A.; Hadrawi, Salema K.; Suliman, Muath; Lorenzo, Ritamaria Di; Laneri, Sonia

doi:10.3390/nano12244468

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…Figure 3 shows the N 2 adsorption/desorption of coppercontaining MOF nanostructures A), cobalt-containing MOF nanostructures B), Cu/Co-hybrid MOF nanostructures C), and Cu/Co-hybrid MOF/PVA fiber nanostructures D). As can be seen, classical isotherms of all compounds were similar to the fourth type (Asiri et al, 2022) Frontiers in Materials frontiersin.org…”

Section: Cytotoxicity Activitymentioning

confidence: 54%

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Asiri,

Jawad BahrAluloom,

Abdullateef Alzubaidi

et al. 2023

Front. Mater.

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Several biological properties of metal–organic frameworks (MOFs) and fiber compounds have been reported, and combinations of these structures can have unique properties. In this study, copper-containing and cobalt-containing MOF nanostructures were synthesized by the ultrasonic technique. Then, novel Cu/Co-hybrid MOF nanostructures were synthesized using the ultrasonic method. Synthesized Cu/Co-hybrid MOF nanostructures were used as a new and efficient recyclable catalyst in the synthesis of pyrano[2,3-c]pyrazole derivatives using the four-component reaction of phenylhydrazine, ethyl acetoacetate, malononitrile, and aldehyde. In the following, novel Cu/Co-hybrid MOF/PVA (poly vinyl alcohol) fiber nanostructures were synthesized by electrospinning and using Cu/Co-hybrid MOF nanostructures and PVA. The structures of the Cu/Co-hybrid MOF nanostructures and the Cu/Co-hybrid MOF/PVA fiber nanostructures were identified and confirmed using BET, TGA, FTIR, SEM, and XRD. In biological studies, the antibacterial, antifungal, and cytotoxicity activities of Cu/Co-hybrid MOF and Cu/Co-hybrid MOF/PVA fiber nanostructures were evaluated. In investigating the catalytic activity of Cu/Co-hybrid MOF, pyrano[2,3-c]pyrazole derivatives were synthesized with higher efficiency and less time than previously reported methods. High antibacterial (against gram-negative and gram-positive strains) and antifungal properties of synthesized Cu/Co-hybrid MOF nanostructures and Cu/Co-hybrid MOF/PVA fiber nanostructures were observed (MIC between 16 and 256 μg/mL), which were higher than some commercial drugs. In the investigation of cytotoxicity activity, the effectiveness on breast cancer cells was studied. The maximum cell proliferation and viability for Cu/Co-hybrid MOF and Cu/Co-hybrid MOF/PVA fiber nanostructures were 38% and 38% higher than the control in a concentration of 200 μg/mL after 48 h. The high catalytic and biological properties of the synthesized nanoparticles can be attributed to the presence of nano-sized bioactive metals and their high specific surface area. The significant physical-chemical properties obtained for synthesized nanoparticles in this study can be related to the desirable synthesis methods, the development of materials with high purity, and the incorporation of hybrid compounds into the nanostructures.

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Section: Cytotoxicity Activitymentioning

confidence: 54%

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Asiri,

Jawad BahrAluloom,

Abdullateef Alzubaidi

et al. 2023

Front. Mater.

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“…Comparing the effects of Cu/DPA-MOF and Cu/DPA-MOF/OP/CS hydrogel shows that the Cu/DPA-MOF/OP/CS hydrogel was relatively more effective than Cu/DPA-MOF. The reason can be attributed to the specific surface area, and as mentioned, a higher specific surface area causes more effectiveness and efficiency in nanoparticles ( Asiri et al, 2022 ; Suksatan et al, 2022 ; Zeraati et al, 2022 ).…”

Section: Resultsmentioning

confidence: 97%

“…Based on the BET results, the specific surface area for Cu/DPA-MOF and Cu/DPA-MOF/OP/CS hydrogel was obtained as 28.200 m 2 /g and 37.700 m 2 /g, respectively. Based on previous studies, the high specific surface area is an essential factor in the reactivity, properties, and performance of nanoparticles ( Asiri et al, 2022 ; Zeraati et al, 2022 ). Therefore, it can be suggested that the polymerization of Cu/DPA-MOF Cu/DPA by oxidized pectin and chitosan caused a significant increase in the specific surface area.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Jasim Al-Khafaji,

Alsalamy,

Abed Jawad

et al. 2023

Front. Chem.

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Today, with the indiscriminate use of antibiotics, we face the resistance of some bacterial strains against some antibiotics. Therefore, it is essential to report and synthesize new compounds with antimicrobial properties. A novel copper/dipicolinic acid–metal–organic framework cross-linked oxidized pectin and chitosan (Cu/DPA-MOF/OP/CS) hydrogel polymer was synthesized under environmental conditions with the controllable process, which uses biodegradable polymer compounds such as pectin and chitosan in its structure. The efficient physicochemical features of the synthesized Cu/DPA-MOF/OP/CS hydrogel using SEM, FT-IR, TGA, BET, XRD, and EDS/mapping were identified and confirmed. The newly synthesized Cu/DPA-MOF/OP/CS hydrogel showed activity against Gram-positive and Gram-negative bacterial strains and fungal species, and significant antibacterial and antifungal properties were observed. In antibacterial activity, the MIC against Gram-positive species was in the range of 16–128 mg/mL, the MIC against Gram-negative species was in the range of 64–256 mg/mL, and the MIC against fungal species was in the range of 128–512 mg/mL. In antimicrobial evaluations, in addition to the MIC test, the MBC test, the MFC test, and the IZD test were performed, and the results were reported. The results were compared with commercial antibiotics in the market. Development of novel nanostructures based on hydrogel polymers with distinctive functionality can affect the performance of these nanostructures in different areas.

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“…The FT-IR spectrum of the synthesized Cu-MOF and penicillinoate@Cu-MOF showed peaks related to Cu-O, C=N, C=C, and C-H at 508 cm −1 ( Elango et al, 2018 ), 1,489 cm −1 ( Abdtawfeeq et al, 2022 ), and 1,535 cm −1 ( Asiri et al, 2022 ), respectively. As can be seen from the comparison in Figure 5 , in the FT-IR spectrum of penicillinoate@Cu-MOF, the peaks corresponding to C-S, aliphatic ketones, and beta-lactam C=O were observed at 790 cm −1 ( Bastian Jr and Martin, 1973 ; Bayati and Wei, 2014 ; Moghaddam-Manesh et al, 2020b ), 1722 cm −1 ( Bayati and Wei, 2014 ), and 1747 cm −1 ( Thumanu et al, 2006 ; Esmaeilpour et al, 2016 ; Al-Adhami et al, 2020 ), respectively.…”

Section: Resultsmentioning

confidence: 99%

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Abdulkadhim,

Husein Kamona,

Shamikh Al-Saedi

et al. 2024

Front. Chem.

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Recently, nanoscience, especially metal–organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal–organic frameworks (Cu-MOFs), a new penicillinoate@copper metal–organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were determined using FT-IR spectrums, EDAX analysis, elemental analysis, XRD patterns, SEM images, nitrogen adsorption/desorption curves, and TGA curve. Then, its antimicrobial effects were evaluated on numerous Gram-positive and Gram-negative bacterial strains and were compared with those of penicillin and gentamicin. In continuation of the biological activities, antioxidant tests were performed on the compounds using the DPPH method. For biological activities, the synthesized penicillinoate@Cu-MOF is much more effective than penicillin and Cu-MOF. The loading of penicillin on the nanostructure and the presence of copper in the final composition can be attributed to the high antibiotic properties of the synthesized composition.

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Synthesis of New Zirconium Magnetic Nanocomposite as a Bioactive Agent and Green Catalyst in the Four-Component Synthesis of a Novel Multi-Ring Compound Containing Pyrazole Derivatives

Cited by 7 publications

References 57 publications

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

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