Synthesis of New α-Aminophosphonates Based on Cyclohexylamine

Synthesis of Amidophosphates Based on 1-Ethynyl-1-Aminocyclohexane Upon Microwave Activation and their Biological Activity

“…The reaction progress was monitored by thin-layer chromatography (TLC) on the plates with aluminum oxide in various solvent systems, the developer was iodine. (5). 0.01 mol (1.10 g, 0.92 ml) of dimethyl phosphite (2), 0.02 mol (3.08 g, 2.11 ml) of carbon tetrachloride, 0.015 mol (1.52 g, 1.08 ml) of triethylamine and 0.01 mol (1.24 g, 1.36 ml) of 1-ethynyl-1-aminocyclohexane (1) was placed in a 25 ml open flat-bottomed flask.…”

“…Among numerous organophosphorus compounds, the phosphorus-containing derivatives of the alicyclic series are of particular interest, among which many valuable substances with practically useful properties have been synthesized. They can be used in various chemical transformations, and are also useful objects for studying some theoretical issues in organic chemistry [1][2][3][4][5]. Although the number of studies in the field of organophosphorus compounds is ever increasing, some interesting classes of organophosphorus derivatives of alicyclic acetylene-containing amines with various substituents both in the cycle and at the phosphorus atom, remain understudied.…”

“…Although the number of studies in the field of organophosphorus compounds is ever increasing, some interesting classes of organophosphorus derivatives of alicyclic acetylene-containing amines with various substituents both in the cycle and at the phosphorus atom, remain understudied. The compounds of this class are always of interest to researchers due to the variety of chemical transformations and the prospect of their use in various fields of science and technology, which stimulates the development of new methods for the synthesis of their polyfunctional derivatives [4][5][6][7].…”