“…In addition, this behaviour can be attributed to the powerful interaction between synthesized compounds and receptor molecules. [ 28–32 ] When our present work (results and methods) were compared with the findings in recent reported papers (please refer to Table 1) the antibacterial activities inhibition zones in our present work were better than the reported ones. Also the addition of carbon dots increased the size of the inhibition zone compared with individual NiO NPs alone.…”
A nickel oxide nanoparticle (NiO NP) composite with carbon dots (C-dots), (NiO NPs@C-dots) was synthesized, characterized, and then its antibacterial activity was evaluated. NiO NPs were prepared using Buddleja polystachya Fresen leaf extract and Ni(NO 3 ) 2 .6H 2 O as precursors. The C-dots were synthesized from benzene-1,-4-diamine and citric acid.
“…In addition, this behaviour can be attributed to the powerful interaction between synthesized compounds and receptor molecules. [ 28–32 ] When our present work (results and methods) were compared with the findings in recent reported papers (please refer to Table 1) the antibacterial activities inhibition zones in our present work were better than the reported ones. Also the addition of carbon dots increased the size of the inhibition zone compared with individual NiO NPs alone.…”
A nickel oxide nanoparticle (NiO NP) composite with carbon dots (C-dots), (NiO NPs@C-dots) was synthesized, characterized, and then its antibacterial activity was evaluated. NiO NPs were prepared using Buddleja polystachya Fresen leaf extract and Ni(NO 3 ) 2 .6H 2 O as precursors. The C-dots were synthesized from benzene-1,-4-diamine and citric acid.
“…Thus, for the green synthesis of MNPs, 12 basic principles of green chemistry are now becoming a reference guideline for researchers, chemical technologists, and chemists worldwide to develop less dangerous chemical products and byproducts [17][18][19]. Therefore, green nanotechnology is an alternate route for the formation of safe and stable materials using different medicinal plants and thus has experienced for rapid rise [20][21][22][23].…”
Chemically nickel oxide nanoparticles (NiONPs) involve the synthesis of toxic products, which restrict their biological applications. Hence, we developed a simple, eco-friendly, and cost-efficient green chemistry method for the fabrication of NiONPs using fresh leaf broth of Rhamnus triquetra (RT). The RT leaves broth was used as a strong reducing, capping, and stabilizing agent in the formation of RT-NiONPs. The color change in solution from brown to greenish black suggests the fabrication of RT-NiONPs which was further confirmed by absorption band at 333 nm. The synthesis and different physicochemical properties of RT-NiONPs were investigated using different analytical techniques such as UV-Vis (ultraviolet−visible spectroscopy), XRD (X-ray powder diffraction), FT-IR (Fourier-transform infrared spectroscopy), SEM (scanning electron microscopy), TEM (transmission electron microscopy), EDS (energy-dispersive X-ray spectroscopy), DLS (dynamic light scattering) and Raman. Further, RT-NiONPs were subjected to different in vitro biological activities and revealed distinctive biosafe and biocompatibility potentials using erythrocytes and macrophages. RT-NiONPs exhibited potential anticancer activity against liver cancer cell lines HUH7 (IC50: 11.3 µg/mL) and HepG2 (IC50: 20.73 µg/mL). Cytotoxicity potential was confirmed using Leishmanial parasites promastigotes (IC50: 27.32 µg/mL) and amastigotes (IC50: 37.4 µg/mL). RT-NiONPs are capable of rendering significant antimicrobial efficacy using various bacterial and fungal strains. NiONPs determined potent radical scavenging and moderate enzyme inhibition potencies. Overall, this study suggested that RT-NiONPs can be an attractive and eco-friendly candidate. In conclusion, current study showed potential in vitro biological activities and further necessitate different in vivo studies in various animal models to develop leads for new drugs to treat several chronic diseases.
“…The FTIR-KBr analysis of VA silver nanoparticles and VA absolute aqueous extract shows similar peaks at approximately 3500cm −1 and 1630cm −1 which is characteristic of the hydroxyl group (-OH stretching) of alcohol and phenol and aromatic groups (C=C-C) respectively. 12 , 13 There were additional smaller peaks for VA absolute aqueous extract at 1384cm −1 and 1097cm −1 which is characteristic of (C-H bending) and (C-O stretching) vibration of esters, which are free fatty acids of alcohol. 14 , 15 Figure 7 Energy dispersive X-ray (EDX) analysis of VA silver nanoparticles.…”
Purpose: Vernonia amygdalina (VA) is a traditional African herbal medicine that has been reported to possess anticancer properties. However, the anticancer properties of VA silver nanoparticles have not been studied. The aim of the study was to examine and evaluate the anticancer activities of VA leaf extracts and VA silver nanoparticles on the human breast cancer cell line, MCF-7. Methods: VA leaves were extracted using sequential extraction assisted with ultrasound using three different solvents: ethanol, 50% ethanol, and deionized water. The silver nanoparticles were synthesised with VA aqueous extract. Results: The ethanol extract and VA silver nanoparticles inhibit MCF-7 cell proliferation with an average half-maximal inhibitory concentration (IC 50 ) value of 67µg/mL and 6.11µg/ mL, respectively, after 72 hours of treatment. The ethanol extract and VA silver nanoparticles also caused G1 phase cell cycle arrest, induced apoptosis and nuclear fragmentation in MCF-7 cells.
Conclusion:VA ethanol extracts and VA silver nanoparticles decreased the cell viability in MCF-7 cells in a time and dose-dependent manner by inducing apoptosis and causing DNA damage. Further research is needed to elucidate the mechanism of action of VA leaf extracts and VA silver nanoparticles. This study is the first to report on the anticancer activity of VA silver nanoparticles in MCF-7 cells.
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