Synthesis of Nitriles – Synthesis of 4-Cyano Pyrazole, 5-Aminopyrazole Derivatives and the Deamination of 5-Aminopyrazole Derivatives

Abstract

Chemoselective reaction on 3-dimethylamino-2-aroyl-propenenitrile and hydrazine in acidic medium yields 4-cyano pyrazole, where as in basic medium yields 5-amino pyrazoles as major product.

RETRACTED: Feprazone Prevents Free Fatty Acid (FFA)-Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway

“…19,20 As a phenylbutazone derivative, feprazone has a similar structure to phenylbutazone, with the main difference lying in the replacement of the butyl located at the C4 position on the pyrazoline-2,5-dione skeleton with a 3-methylbutenyl substituent. 21 Feprazone and other members of the pyrazolone family have been used for decades owing to their wide range of pharmacological activities, including antipyretic, analgesic, anti-inflammatory, antioxidant, anticancer, and many others. 22−24 In the present study, we investigated whether feprazone might mitigate the effects of FFA in human aortic endothelial cells (HAECs) and explored the underlying mechanism.…”

“…Prostaglandins are a type of fatty acid that trigger pain and inflammation and have been shown to contribute to atherosclerotic plaque rupture by mediating the expression of MMPs . Previous research has demonstrated the involvement of COX-2-mediated prostaglandin production in the pathological mechanism of AS. , As a phenylbutazone derivative, feprazone has a similar structure to phenylbutazone, with the main difference lying in the replacement of the butyl located at the C4 position on the pyrazoline-2,5-dione skeleton with a 3-methylbutenyl substituent . Feprazone and other members of the pyrazolone family have been used for decades owing to their wide range of pharmacological activities, including antipyretic, analgesic, anti-inflammatory, antioxidant, anticancer, and many others. − In the present study, we investigated whether feprazone might mitigate the effects of FFA in human aortic endothelial cells (HAECs) and explored the underlying mechanism.…”