Synthesis of non-fouling poly[N-(2-hydroxypropyl)methacrylamide] brushes by photoinduced SET-LRP

Vorobii, Mariia; Pereira, Andrés de los Santos; Pop‐Georgievski, Ognen; Kostina, Nina Yu.; Rodriguez‐Emmenegger, Cesar; Percéc, Virgil

doi:10.1039/c5py00506j

Cited by 64 publications

(102 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…306 Finally, micropatterns of poly(HPMA) brushes on silicon surface have also been contrasted with this method providing the first example of nonfouling polymer brushes via SET-LRP. 131 …”

Section: Surface Initiated Set-lrpmentioning

confidence: 99%

See 1 more Smart Citation

Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…306 Finally, micropatterns of poly(HPMA) brushes on silicon surface have also been contrasted with this method providing the first example of nonfouling polymer brushes via SET-LRP. 131 …”

Section: Surface Initiated Set-lrpmentioning

confidence: 99%

“…133 The synthesis of nonfouling poly(HPMA) brushes by photoinduced SET-LRP has also been conducted combining the unmatched resistance to fouling of previously reported brushes with the highly versatile living nature of the technique. 131 6.2. Technological Applications 6.2.1.…”

Section: Star Polymersmentioning

confidence: 99%

Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Functional materials play a key role in modern life due to their broad range of applications and versatile properties. Particularly, controlling interactions between artificial surfaces in contact with biological surroundings is key for the success of biomaterials, implants, biosensors, medical devices, and a plethora of other applications . However, this proved challenging because of the need of specific functionalization to address the vastly different surface chemistry of different materials.…”

Section: Ellipsometric Thickness and Grafting Densities Calculated Fomentioning

confidence: 99%

Turning a Killing Mechanism into an Adhesion and Antifouling Advantage

Dedisch

Obstals

Pereira

et al. 2019

Adv Materials Inter

Self Cite

View full text Add to dashboard Cite

Functional materials play a key role in modern life due to their broad range of applications and versatile properties. Particularly, controlling interactions between artificial surfaces in contact with biological surroundings is key for the success of biomaterials, Mild and universal methods to introduce functionality in polymeric surfaces remain a challenge. Herein, a bacterial killing mechanism based on amphiphilic antimicrobial peptides is turned into an adhesion advantage. Surface activity (surfactant) of the antimicrobial liquid chromatography peak I (LCI) peptide is exploited to achieve irreversible binding of a protein-polymer hybrid to surfaces via physical interactions. The protein-polymer hybrid consists of two blocks, a surface-affine block (LCI) and a functional block to prevent protein fouling on surfaces by grafting antifouling polymers via single electron transfer-living radical polymerization (SET-LRP). The mild conditions of SET-LRP of N-2-hydroxy propyl methacrylamide (HPMA) and carboxybetaine methacrylamide (CBMAA) preserve the secondary structure of the fusion protein. Adsorption kinetics and grafting densities are assessed using surface plasmon resonance and ellipsometry on model gold surfaces, while the functionalization of a range of artificial and natural surfaces, including teeth, is directly observed by confocal microscopy. Notably, the fusion protein modified with poly(HPMA) completely prevents the fouling from human blood plasma and thereby exhibits a resistance to protein fouling that is comparable to the best grafted-from polymer brushes. This, combined with their simple application on a large variety of materials, highlights the universal and scalable character of the antifouling concept.

show abstract

“…However, the development of multiphase SET‐LRP has expanded the solvent classes that can be used, including less disproportionating solvents, such as acetonitrile and acetone, and even the mixture of ethanol and water with non‐disproportionating solvents, such as hexanes, cyclohexane, ethyl acetate, diethyl carbonate, toluene, and anisole . These improvements together with the intrinsic advantages of the Cu(0)‐mediated RDRP process, such as high reaction rates, tolerance to air, impurities, and radical inhibitors, and near perfect chain‐end fidelity, make it a method of choice for performing surface initiated RDRP reactions …”

Section: Introductionmentioning

confidence: 99%

“…18 These improvements together with the intrinsic advantages of the Cu(0)-mediated RDRP process, such as high reaction rates, 21 tolerance to air, 16,22 impurities, 23 and radical inhibitors, 24 and near perfect chain-end fidelity, 25 make it a method of choice for performing surface initiated RDRP reactions. [26][27][28][29][30][31][32][33][34][35][36][37][38] Nanoparticles are of great interest to be subjected to surface modification, especially with polymer brushes, because of the vast applications and advantages that the nanoparticles have over more common materials most importantly due to their large surface area. These applications include the immobilization of different adsorbents for separations and/ or removal of different compounds, such as dyes, 39 heavy metals, 40,41 and bovine serum albumin, 42 the immobilization of catalysts and enzymes for increasing thermal stability, enhanced activity and ease of recovery, [43][44][45] the modification of membranes for control of selectivity and biofouling, 46 and the fabrication of superhydrophilic 47 and superhydrophobic surfaces 48 (including sprayable superhydrophobic coatings).…”

mentioning

confidence: 99%

Facile preparation of superhydrophobic and oleophobic surfaces via the combination of Cu(0)‐mediated reversible‐deactivation radical polymerization and click chemistry

Enayati

Abbaspourrad

2018

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

The fabrication of novel hydrophobic, superhydrophobic, and oleophobic surfaces on glass using nanosilica particles modified with polymer brushes prepared via surface initiated Cu(0)‐mediated reversible‐deactivation radical polymerization was demonstrated. Monomers including n‐butyl acrylate, 2,2,2‐trifluoroethyl methacrylate, and 1,1,1,3,3,3‐hexafluoroisopropyl acrylate were used to synthesize a series of nanosilica–polymer organic/inorganic hybrid materials. Products were analyzed using infrared spectroscopy, thermogravimetric analysis, scanning and transmission electron microscopy. The coated nanosilica showed core–shell structures that contains polymer brushes up to 67 wt %. The application of these particles for modifying surface wettability was examined by covalently attaching them to glass via a recently developed one‐pot “grafting to” methodology using “thio‐bromo click” chemistry. Atomic force microscopy topographic images show up to 25 times increase in roughness of the coated glass compared to blank glass sample. Contact angle measurements showed that nanosilica coated with PBA and PTFEM produced hydrophobic glass surfaces, while a superhydrophobic and oleophobic surface was generated using nanosilica functionalized with PHFIPA. This novel methodology can produce superhydrophobic and oleophobic surfaces in an easy and fast way without the need for tedious and time‐consuming processes, such as layer‐by‐layer deposition, high temperature calcination, and fluorinated oil infusion. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018

show abstract

Synthesis of non-fouling poly[N-(2-hydroxypropyl)methacrylamide] brushes by photoinduced SET-LRP

Abstract: Surface-initiated photoinduced SET-LRP of N-(2-hydroxypropyl)methacrylamide from an initiator-containing monolayer yields micropatterned brushes resistant to blood plasma fouling.

Cited by 64 publications

References 76 publications

Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis

Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis

Turning a Killing Mechanism into an Adhesion and Antifouling Advantage

Facile preparation of superhydrophobic and oleophobic surfaces via the combination of Cu(0)‐mediated reversible‐deactivation radical polymerization and click chemistry

Contact Info

Product

Resources

About