Synthesis of Norbornene Derived Helical Copolymer by Simple Molecular Marriage Approach to Produce Smart Nanocarrier

Abstract

A novel library of norbornene derived helical copolymer has been synthesized through the coupling of two homopolymers via Molecular Marriage Approach. The helicity is governed by the non-covalent interactions like hydrogen bonding, π-π stacking and the influence of hydrophobic and hydrophilic motifs. The detailed characterization of the copolymer (Copoly 1) has been provided and the super structures are confirmed through dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The observed size of the aggregates was about 200 nm. The density functional theory (DFT) is favorably supported for the formation of proposed structure of Copoly 1. Circular dichroism (CD) measurement has confirmed the one handed helical structure of the copolymer. Reservoir capability of this pH responsive polymer (Copoly 1) to encapsulate anti-cancer drug doxorubicin (DOX) warrants its potential applications in the field of bio-medical sciences.

Polymer based Nano-Assemblies: Very Efficient Carrier in the Field of Cancer Chemotherapy

“…nanoparticles, peptides, dendrimer, and liposomes) have been explored by the researchers which efficiently carries the drug to the targeted sites [4]. These all particularly form excellent nano-assemblies in aqueous environment due its amphiphilicity present in it [14][15][16][17][18]. Polymer based drug delivery system is one of those which form excellent nano-assemblies when it functionalized with hydrophilic PEG group [7,9,[11][12][13].…”

“…Polymer based drug delivery system is one of those which form excellent nano-assemblies when it functionalized with hydrophilic PEG group [7,9,[11][12][13]. The drug can deliver through this nano-carrier either by non-covalent encapsulation or covalently attached with different stimuli responsive linkers [5,7,[13][14][15]. The polymer based nano-vehicle shows enhanced cytotoxic effect due to its plasma stability which eventually helps to increase the permeation and retention effect (EPR) [5][6][7][8][9][10][11][12][13][14][15].…”

“…The drug can deliver through this nano-carrier either by non-covalent encapsulation or covalently attached with different stimuli responsive linkers [5,7,[13][14][15]. The polymer based nano-vehicle shows enhanced cytotoxic effect due to its plasma stability which eventually helps to increase the permeation and retention effect (EPR) [5][6][7][8][9][10][11][12][13][14][15]. Due to leaky vesicular nature of the blood vessel around the tumour help these nano-vehicles to reach the targeted sites [8].…”

“…Different polymeric methods with different backbones (e.g. ROP, poly-condensation, ROMP), have already been explored by different research groups to employ various functionalities for synthesizing smart carriers in the field of nano-medicine [5][6][7][8][9][10][11][12][13][14]. These different polymeric system shows excellent nanoassembly [5][6][7][8][9][10][11][12][13][14].…”

“…ROP, poly-condensation, ROMP), have already been explored by different research groups to employ various functionalities for synthesizing smart carriers in the field of nano-medicine [5][6][7][8][9][10][11][12][13][14]. These different polymeric system shows excellent nanoassembly [5][6][7][8][9][10][11][12][13][14]. Upon incorporation of drugs into that by either covalent or non-covalently form different shapes at nano-scale level and internalize inside the cell quite efficiently [5][6][7][8][9][10][11][12][13][14][15].…”