Synthesis of novel 1,2,4-triazole derivatives containing the quinazolinylpiperidinyl moiety and N-(substituted phenyl)acetamide group as efficient bactericides against the phytopathogenic bacterium Xanthomonas oryzae pv. oryzae

Abstract

Some 1,2,4-triazole derivatives containing the quinazolinylpiperidinyl moiety andN-(substituted phenyl)acetamide group were developed as efficient bactericides against pathogenic bacteriumXoo.

Synthesis and Antimicrobial Activities of Novel Quinazolinone Acylhydrazone Derivatives Containing the Indole Moiety

“…Antibacterial activities of target compounds 7a – 7r against three pathogenic bacteria ( Xoo , Rs , and Xac ) were firstly evaluated at 200 and 100 μg/mL in vitro , based on the turbidimetric method . At the same time, commercial agrobactericides Bismerthiazol (BMT) and Thiodiazole‐copper (TDC) were chosen as positive control agents.…”

“…The synthesized compounds were evaluated for antibacterial activity against Xoo and Xcc in vitro by the turbidimeter test . Commercial agricultural antibacterial Bismerthiazol was used as control.…”

An insight on medicinal attributes of 1,2,4-triazoles

“…Yang and Bao synthesized 1,2,4-triazole derivatives 50 bearing quinazolinylpiperidinyl moiety and N -(substituted phenyl)acetamide unit ( Fig. 8 ) and evaluated them for their antimicrobial activities [ 66 ]. Compounds 50e , 50g , 50i , 50l and 50n (EC 50 : 34.5–47.5 μ g/mL) had better bactericidal activity than control bismerthiazol (85.6 μ g/mL) against phytopathogenic bacterium X. oryzae pv.…”

Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

“…By considering the diverse range of activities of quinazoline and triazole scaffolds, Yang et al designed hybrid analogues by linking these motifs together. 109 Molecules were designed with the following rationale: (a) 1,2,4-triazole-based analogues are well reported with anti-bacterial activities, 105,110,111 with Triadimefon, Triadimenol, Diniconazole, Flusilazole, and Difenoconazole, which are clinically used agrofungicides. (b) The quinazoline moiety is found in many pesticidal drugs such as Fluquinconazole and Pyriuquinazon.…”