Synthesis of Novel 2-Amino-(2-thioxo-3-alkyl-4-methyl-3H-thiazol-5-yl)-[1,3,4]thiadiazole Derivatives and Their Growth Stimulant Activity

Abstract

in Wiley Online Library (wileyonlinelibrary.com).On the base of synthesized 2-amino and 2-ethylamino-(2-thioxo-3-alkyl-4-methyl-3H-thiazol-5-yl)-[1,3,4]thiadiazoles, their alkyl, acetyl, and alkylacetylamino derivatives are obtained. The alkylation of 2ethylamino derivatives can occur at both exo and endo nitrogen atoms of amidine group, and the acetylation takes place exclusively at the exocyclic nitrogen atom. At acetylation of 2-amino-[1,3,4]thiadiazoles, only exo substitution is observed. At the further alkylation of these products, a mixture of exo-and endo-substituted forms is obtained. At preliminary screening, the synthesized compounds have shown expressed growth stimulant properties. The activity of the most active derivatives was in the range of 65-100%, compared with that of heteroauxin.