Synthesis of Novel 2-Thienylimino-1,3-thiazolidin-4-ones

Abstract

The preparation of new 2-thienylimino-1,3-thiazolidin-4-ones from 3-aminothiophene-2-carboxylate using an easy fourstep procedure is described.

Design, synthesis andin vitrocytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors

“…The synthesis of thiazolidinone-grafted indolo–pyrazole conjugates 6a–ah was achieved through previously reported synthetic approaches 26 and is depicted in Scheme 1. The synthesis was initiated from commercially available indoles 1a–c , which were initially N -alkylated with alkyl halides in the presence of a base to generate N -alkyl indoles 2a–h .…”