“…Badiger et al [ 9 ] synthesized novel thiazolidinediones derived from 4-fluorophenylacetic acid and thiosemicarbazide in phosphorous oxychloride using Scheme 5 . The in vitro antidiabetic activity of synthesized compound [5-{[2-(4-alkyl/aryl)-6-arylimidazo[1,2][1,3,4]thiadiazol-5-yl]metylene}-1,3-thiazolidine-2,4-dione] were performed by alloxan induced tail tipping method.…”
Section: Biological Activities Of Thiazolidinediones Derivatives In Tmentioning
confidence: 99%
“…Among them, compounds 9 and 10 found to be most active due to presence of napthyl and coumarinyl groups at C 5 position as compared to standard drug pioglitazone. The results of synthesized compounds presented in Table 5 (Badiger et al [ 9 ]). Scheme 5 Synthesis of 5-{[2-(4-Fluorobenzyl)-6-arylimidazo[2,1- b ] [1, 3, 4] thiadiazol-5-yl]methylene}thiazolidine-2,4-diones …”
Section: Biological Activities Of Thiazolidinediones Derivatives In Tmentioning
Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. However, owing to the swift development of new molecules containing this nucleus, many research reports have been generated in a brief span of time. Therefore seems to be a requirement to collect recent information in order to understand the current status of the thiazolidinedione nucleus in medicinal chemistry research, focusing in particular on the numerous attempts to synthesize and investigate new structural prototypes with more effective antidiabetic, antimicrobial, antioxidant, anti-inflammatory, anticancer and antitubercular activity.
“…Badiger et al [ 9 ] synthesized novel thiazolidinediones derived from 4-fluorophenylacetic acid and thiosemicarbazide in phosphorous oxychloride using Scheme 5 . The in vitro antidiabetic activity of synthesized compound [5-{[2-(4-alkyl/aryl)-6-arylimidazo[1,2][1,3,4]thiadiazol-5-yl]metylene}-1,3-thiazolidine-2,4-dione] were performed by alloxan induced tail tipping method.…”
Section: Biological Activities Of Thiazolidinediones Derivatives In Tmentioning
confidence: 99%
“…Among them, compounds 9 and 10 found to be most active due to presence of napthyl and coumarinyl groups at C 5 position as compared to standard drug pioglitazone. The results of synthesized compounds presented in Table 5 (Badiger et al [ 9 ]). Scheme 5 Synthesis of 5-{[2-(4-Fluorobenzyl)-6-arylimidazo[2,1- b ] [1, 3, 4] thiadiazol-5-yl]methylene}thiazolidine-2,4-diones …”
Section: Biological Activities Of Thiazolidinediones Derivatives In Tmentioning
Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. However, owing to the swift development of new molecules containing this nucleus, many research reports have been generated in a brief span of time. Therefore seems to be a requirement to collect recent information in order to understand the current status of the thiazolidinedione nucleus in medicinal chemistry research, focusing in particular on the numerous attempts to synthesize and investigate new structural prototypes with more effective antidiabetic, antimicrobial, antioxidant, anti-inflammatory, anticancer and antitubercular activity.
“…Badiger et al derived a series of thiazolidine-2,4-diones derivatives with a 1,3,4-thiadiazole scaffold and screened them for their in vivo antidiabetic activity using an alloxan-induced tail tipping diabetic model of Wistar albino rats in comparison to the standard drug pioglitazone. Amongst all the synthesized derivatives, molecules ad34 and ad35 exhibited significant activity ( Table 45 , Figure 16 ) [ 80 ].…”
Section: Biological Potential Of the Thiazolidin-24-dione Analoguesmentioning
Heterocyclic compounds containing nitrogen and sulfur, especially those in the thiazole family, have generated special interest in terms of their synthetic chemistry, which is attributable to their ubiquitous existence in pharmacologically dynamic natural products and also as overwhelmingly powerful agrochemicals and pharmaceuticals. The thiazolidin-2,4-dione (TZD) moiety plays a central role in the biological functioning of several essential molecules. The availability of substitutions at the third and fifth positions of the Thiazolidin-2,4-dione (TZD) scaffold makes it a highly utilized and versatile moiety that exhibits a wide range of biological activities. TZD analogues exhibit their hypoglycemic activity by improving insulin resistance through PPAR-γ receptor activation, their antimicrobial action by inhibiting cytoplasmic Mur ligases, and their antioxidant action by scavenging reactive oxygen species (ROS). In this manuscript, an effort has been made to review the research on TZD derivatives as potential antimicrobial, antioxidant, and antihyperglycemic agents from the period from 2010 to the present date, along with their molecular mechanisms and the information on patents granted to TZD analogues.
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