Synthesis of novel bioactive phthalimido-4-methyl pentanoateorganotin(IV) esters with spectroscopic investigation

Diorganotin (IV) complexes with 4-nitro-N-phthaloyl-glycine: Synthesis, characterization, antitumor activity and DNA-binding studies

“…The absorption bands of Sn-C and Sn-O were exhibited at 576 and 472 cm À1 for both complexes 1-2. Asymmetric and symmetric stretching of the 4-nitro-phthalimide group (C 2 O 2 N) and (NO 2 ) were found at 1782, 1730 cm À1 and 1539, 1346 cm À1 for 1, 1780, 1731 cm À1 and 1537, 1359 cm À1 for 2, and 1785, 1731 cm À1 and 1550, 1350 cm À1 for HL, as reported in the literature [17].…”

Antiproliferative and anti-tumor activity of organotin compounds

“…The di-n-butyl-, tricyclohexyl-and triphenyl-tin(IV) complexes with phthalimido-4-methylpentanoic acid (HPMPA) (Scheme 2D) of formulae (PMPA) 2 Sn(n-Bu) 2 (19), [{(PMPA)Sn(n-Bu) 2 } 2 O] 2 (20), [(C 6 H 5 ) 3 Sn(PMPA)] (21) and [(c-Hex) 3 Sn(PMPA)] (22) (Scheme 1D, E, and G) [24] have been studied for their in vitro, antiproliferative activity ID 50 Table 1).…”

Review on supermolecules as chemical drugs

“…Furthermore, some Sn(Ⅳ)/Ru(Ⅱ,Ⅲ)-NSAIDs complexes have also been prepared and characterized [123,124] , but few studies were involved in their anti-inflammatory activity. Organotin(IV) complexes of 2-maleimidoacetic acid displayed stronger analgesic activity than its parent, while phthalimido-4-methyl pentanoate(PMPA) organotin(Ⅳ) esters showed less activity than the ligand [125,126] . Not only the NSAIDs metal complexes could reduce the gastro-intestinal damage of NSAIDs, but also the organic complex supramolecules formed by CD and their derivatives with NSAIDs, could improve their pharmacodynamics and pharmacokinetics properties.…”