Synthesis of novel bioactive pyrido[2,3-<i>d</i>]pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors

Tantawy, Eman S.; Nafie, Mohamed S.; Morsy, Hesham A.; El-Sayed, Hassan A.; Moustafa, Ahmed H.; Mohammed, Samar M.

doi:10.1039/d4ra00902a

RSC Adv.

2024

DOI: 10.1039/d4ra00902a

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Synthesis of novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors

Eman S. Tantawy,

Mohamed S. Nafie,

Hesham A. Morsy

et al.

Abstract: Novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent apoptotic inducers as PIM-1 kinase inhibitors.

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2024

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Cited by 3 publications

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Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Anjirwala,

Patel

2024

Journal of Heterocyclic Chem

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Pyrimidine and its derivatives play a paramount role in drug discovery as privileged pharmacophores with considerable chemical and biological significance and its presence in genes. This review aims to assemble a systematic evaluation of synthetic tactics of various fused pyrimidine derivatives containing nitrogen heterocycles such as pyridopyridines, pyridopyrimidines, and pyrimidopyrimidine from a pharmacological point of view and deliver an overview of methodologies presenting the chemistry of fused pyrimidine derivatives. The review details the importance of various catalysts and ring substitution using various electrophilic and nucleophilic reagents. These synthetic strategies were elaborated based on the different synthetic routes that lead to the specific type of pyrimidine and pyridine fused derivatives. The literature accumulates various developments in one‐pot condensation, the Knoevenagel–Michael addition mechanism, microwave and ultrasound irradiation, intramolecular cyclization, nano‐catalytic reactions, and so forth. Short reaction times, catalyst reusability, solvent‐free conditions, excellent yields, and stereo‐selectivity are some of the benefits of certain synthetic approaches.

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Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Anjirwala,

Patel

2024

Journal of Heterocyclic Chem

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Synthetic approaches for novel annulated pyrido[2,3-d]pyrimidines: Design, Structural Characterization, Fukui functions, DFT Calculations, Molecular docking and Anticancer efficiency

Hussain,

Ibrahim,

Hassanin

et al. 2024

Journal of Molecular Structure

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Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators

Nafie,

Hamza,

Moustafa

et al. 2024

RSC Adv.

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Synthesis of novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors

Abstract: Novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent apoptotic inducers as PIM-1 kinase inhibitors.

Cited by 3 publications

References 32 publications

Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Synthetic approaches for novel annulated pyrido[2,3-d]pyrimidines: Design, Structural Characterization, Fukui functions, DFT Calculations, Molecular docking and Anticancer efficiency

Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators

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