Synthesis of novel core-shell structured dual-mesoporous silica nanospheres and their application for enhancing the dissolution rate of poorly water-soluble drugs

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

“…Significant decrease of the surface area, pore volume and pore size of the functionalized and Cur-loaded samples compared to the calcined materials confirms, that the drug molecules indeed filled pore spaces ( Figure 2 and Table 1). These results agreed with the previous studies [44][45][46][47].…”

“…This is consistent with the previous studies [36,46,48]. It was shown that non-crystalline form of the drug placed in mesoporous silica can present increased solubility [45]. Therefore we expect enhanced solubility of Cur in our samples.…”

“…It means that the Cur had been completely converted to a non-crystalline state when it was loaded into amine-functionalized silica materials. These results were in consistent with the results of a previous studies obtained by [45,46,48,49]. The DSC results confirmed the XRD characterization.…”

“…Determination of drug loading efficiency by TGA analysis: TGA is an important technique to quantify the drug loading content together with drug loading efficiency in mesoporous silica nanocarriers [45,48]. The aminopropyl functional groups contents were quantified using TGA analysis after correction the TG curve by water content (Figure 3) not, can be obtained from depression of the melting point as a standard means [46].…”

“…In order to show the changes of surface chemistry of different state of samples only selected range of FTIR spectra are shown. MCM-Calcinated and KCCCalcined showed the wide absorption bands in the range of 3750 to 3000 cm -1 due to the O-H stretching vibration of water ( Figure 6A) [45,47]. Presence of water was due to defective Si-OH on the surface, so that water molecules could be adsorbed and retained by hydrogen bonding.…”