Synthesis of novel Cu(II) complexes with N2O2 ligands: Characterization, theoretical calculations, antimicrobial, antioxidant, DNA binding, and in vitro anticancer activity studies

Mermer, Arif; Tüzün, Burak; Daştan, Sevgi Durna; Çevik, Özge

doi:10.1016/j.poly.2023.116487

Cited by 6 publications

(1 citation statement)

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“…Being a catalytic and structural cofactor of many enzymes, copper is an essential element for numerous aerobic organisms. Copper(II) complexes were found to be powerful antibacterial, [2][3][4][5][6] antifungal, 7,8 anticancer, 7,[9][10][11] and DNA-cleavage agents. 12,13 Only in the last two decades, the synthesis of more than hundreds of copper(I,II) complexes has been reported, and their anticancer properties have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Cu(ii) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

Selaković,

Rodić,

Novaković

et al. 2024

Dalton Trans.

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Section: Introductionmentioning

confidence: 99%

Cu(ii) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

Selaković,

Rodić,

Novaković

et al. 2024

Dalton Trans.

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Peripheral (E)‐2‐[(4‐hydroxybenzylidene)‐3,4‐dihydronaphthalen‐1(2H)‐one)]‐coordinated phthalocyanines with improved enzyme inhibition properties and photophysicochemical behaviors

Güleç,

Bilgiçli,

Tüzün

et al. 2024

Archiv der Pharmazie

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In this study, (E)‐4‐{4‐[(1‐oxo‐3,4‐dihydronaphthalen‐2(1H)‐ylidene)methyl]phenoxy}phthalonitrile (4) and its phthalocyanine derivatives (5–8) were synthesized for the first time. Aggregation behaviors of the novel soluble phthalocyanines in organic solvents were investigated. In addition, the efficiency of 1O2 production of (5) and ZnPc (6) was investigated. The singlet oxygen quantum yields (ΦΔ) for 2HPc (5) and ZnPc (6) were found to be 0.58 and 0.83, respectively. Additionally, novel phthalocyanines (5–8) were investigated for their ability to inhibit enzymes. They exhibited a highly potent inhibition effect on human carbonic anhydrase I and II (hCA I and II) and α‐glycosidase (α‐Gly) enzymes. Ki values are in the range of 2.60 ± 9.87 to 11.53 ± 6.92 µM, 3.35 ± 0.53 to 15.47 ± 1.20 µM, and 28.60 ± 4.82 to 40.58 ± 7.37 nM, respectively. The calculations of the studied molecule at the B3LYP, HF, and M062X levels in the 6–31G basis sets were made using the Gaussian package program. Afterward, the interactions occurring in the docking calculation against a protein that is the crystal structure of hCA I (PDB ID: 2CAB), the crystal structure of hCA II (PDB ID: 5AML), and the crystal structure of α‐Gly (PDB ID: 1R47), were examined. Following that, Protein–Ligand Interaction Profiler (PLIP) analysis was used to look at the interactions that occurred during the docking calculation in further detail.

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In-situ Salen-type ligand formation-driven of a heterometallic Cu(II)-Hg(II) complex: Synthetic update, crystallographic features, DFT calculations, and unveil antimicrobial profiles

Majumdar,

Roy,

Elizabeth Philip

et al. 2024

Inorganic Chemistry Communications

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Synthesis of novel Cu(II) complexes with N2O2 ligands: Characterization, theoretical calculations, antimicrobial, antioxidant, DNA binding, and in vitro anticancer activity studies

Cited by 6 publications

References 57 publications

Cu(ii) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

Cu(ii) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

Peripheral (E)‐2‐[(4‐hydroxybenzylidene)‐3,4‐dihydronaphthalen‐1(2H)‐one)]‐coordinated phthalocyanines with improved enzyme inhibition properties and photophysicochemical behaviors

In-situ Salen-type ligand formation-driven of a heterometallic Cu(II)-Hg(II) complex: Synthetic update, crystallographic features, DFT calculations, and unveil antimicrobial profiles

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