Synthesis of Novel CuO Nanosheets with Porous Structure and Their Non‐Enzymatic Glucose Sensing Applications

Sun, Fangfang; Zhu, Rongfeng; Jiang, Hongwei; Huang, Hailiang; Liu, Peng; Zheng, Youjin

doi:10.1002/elan.201400623

Cited by 17 publications

(9 citation statements)

References 45 publications

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“…CuO, as a p-type semiconductor, plays an important role in glucose detection owing to its high catalytic activity, low toxicity, and simple preparation process [113,114]. To date, various CuO nanostructures have been prepared as active materials for glucose sensors such as nanowires [115], nanoplates [116], and nanoflowers [117]. However, CuO exhibits poor conductivity, which can be improved by integrating with metal nanostructures.…”

Section: Metal/cuo Composite-based Electrodementioning

confidence: 99%

Metal oxide-based composite for non-enzymatic glucose sensors

Liu

Zeng

Guo

et al. 2020

J Mater Sci: Mater Electron

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The increasing demand for monitoring the glucose concentration in the blood of diabetic patients has aroused the attention of researchers to prepare high-performance glucose biosensors. After decades of development, enzyme-based biosensors have gradually matured and commercialized, but they still suffer from insufficient stability due to the inherent defects of the enzyme. Non-enzymatic glucose sensor was proposed to address this issue. The introduction of nanotechnology has provided more possibilities for the preparation of highly efficient catalytic materials. Among the synthesized electrocatalysts, metal oxides are one of the most important components owing to their outstanding properties. Recent studies have integrated metal oxides with other materials to further improve sensor performance. This review focuses on the application of metal oxide-based hybrid structure in the glucose sensor, mainly including metal oxide/metal oxide, metal/metal oxide, and carbon material/metal oxide. The preparation method, electrochemical properties, and catalytic mechanism of the sensors are discussed in detail. Finally, we present some of the existing challenges and make personal predictions for the future development of non-enzymatic glucose sensors.

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Section: Metal/cuo Composite-based Electrodementioning

confidence: 99%

Metal oxide-based composite for non-enzymatic glucose sensors

Liu

Zeng

Guo

et al. 2020

J Mater Sci: Mater Electron

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“…2,7,14 Importantly, the XRD patterns also show that the peaks due to metallic Cu have disappeared. Other peaks are due to the (underlying) ITO electrode support as in Figure S2.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Pt-CuO Nanocomposite Films for Non-Enzymatic Glucose Sensor Application

Myung

Kim

Lee

et al. 2016

J. Electrochem. Soc.

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Nanocomposite films of Pt-CuO were synthesized via galvanostatic electrodeposition combined with galvanic replacement and post-synthesis thermal anneal. First, Cu-Cu 2 O composite was prepared by galvanostatic electrodeposition; heat-treatment of the as-prepared Cu-Cu 2 O composite at 375 • C for 10 h resulted in a CuO electrode showing response to glucose with long term stability. Further enhanced response to glucose was obtained with a Pt-CuO electrode, which was synthesized by galvanic replacement of Cu-Cu 2 O in 10 mM PtCl 4 solution for 30 s followed by annealing at 375 • C for 10 h. The resulting Pt-CuO electrode showed excellent response to glucose in alkaline solution with an analytical sensitivity of 3812 μAmM −1 cm −2 , a limit of detection (LOD) of 7.5 μM, and a linear response range to glucose up to 0.6 mM. These results may be extended to the fabrication of other noble metal-metal oxide nanocomposite electrodes for sensor applications. Millions of people worldwide are afflicted with diabetes, a disease necessitating regular monitoring of blood glucose levels. Amperometric sensing 1-13 is a particularly popular approach to glucose sensing but classical methodology is based on enzymatic monitoring using glucose oxidase which oxidizes the catalytic conversion of glucose to glucolactone. However, a perennial problem with the enzymatic approach is the lack of long term stability and robustness of the sensing device. In terms of selectivity and sensitivity, enzymatic sensors do generally exhibit better performance than non-enzymatic ones. 1,2,5,6 However, as noted earlier, they suffer from several problems including poor stability, high cost, fragility of the enzyme component, and difficulty of active sensing component preparation. 1,2,[5][6][7] Non-enzymatic approaches, therefore, have gained traction in recent years. Thus non-enzymatic amperometric sensors [8][9][10][11][12][13] have been electrosynthesized using MnO 2 , CuO, or cobalt oxide/hydroxide as the active sensor materials. Several reviews are available in the area of non-enzymatic glucose sensors. [8][9][10][11][12][13] Among the non-enzymatic glucose sensing components based on metals and metal oxides, CuO is one of the more promising materials due to its low cost, high stability and earth abundance.2,14 Copper(II) oxide (CuO) which is a p-type semiconductor with a bandgap 1.2 eV has been widely used in many applications including catalyst, gas sensor, battery, and biosensor. [3][4][5][6][7] This inorganic semiconductor has also shown good electrochemical activity and capability of promoting facile electron transfer rates at low overpotentials in alkaline electrolytes. 15Noble metals such as Pt, Au and Ag have been extensively used to improve sensing performance due to their excellent electrocatalytic activity and biocompatibility.2 Especially, Pt-based metal oxides have been proposed for improving the sensitivity and selectivity of non-enzymatic glucose sensors.1,2,4 Unlike CuO-based glucose sensors, however, there is more limited precedent ...

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“…Figure 4a plots the CVs of these modified FTO electrodes showing that the oxidation peak has a similar range (0.2–0.7 V vs Ag/AgCl) but with varying intensity. The corresponding signal‐to‐background ratio (S/B) [ 31 ] around the oxidation peak shoulder (0.4–0.5 V) was calculated and is plotted in Figure 4b. The position of maximum S/B value shifts from 0.4 to 0.45 V as the Cu content increases, indicating that the Cu oxides can help to decrease the detection potential.…”

Section: Resultsmentioning

confidence: 99%

Flexible Nonenzymatic Glucose Sensing with One‐Step Laser‐Fabricated Cu₂O/Cu Porous Structure

et al. 2021

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Integrated flexible nonenzymatic electrochemical glucose sensors have attracted substantial interest because they enable portable noninvasive glucose detection stably and accurately. Manufacturing of these sensors generally requires complex step‐by‐step processes, including synthesis of noble and functional materials, patterning the as‐synthesized noble materials into electrodes/contacts, and subsequent working electrode functionalizing. Herein, the one‐step fabrication of a working electrode and electrical contacts on a flexible substrate for an integrated sensor is realized through laser writing of a low‐cost Cu ionic precursor. The obtained Cu2O/Cu porous structure not only has a low sheet resistance of 1.3 Ω sq−1 to ensure signal transmission in the sensor, but also provides a remarkable sensing performance for glucose detection, especially at a low detection potential of 0.3 V and a low detection limit of 0.34 μm. Due to its anti‐interference and flexibility, the integrated sensor has the potential to directly detect trace amounts of glucose in body fluids as demonstrated in sweat sensing. This work highlights an efficient route to fabricate low‐cost integrated flexible electrochemical sensors.

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Synthesis of Novel CuO Nanosheets with Porous Structure and Their Non‐Enzymatic Glucose Sensing Applications

Cited by 17 publications

References 45 publications

Metal oxide-based composite for non-enzymatic glucose sensors

Metal oxide-based composite for non-enzymatic glucose sensors

Facile Synthesis of Pt-CuO Nanocomposite Films for Non-Enzymatic Glucose Sensor Application

Flexible Nonenzymatic Glucose Sensing with One‐Step Laser‐Fabricated Cu₂O/Cu Porous Structure

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Synthesis of Novel CuO Nanosheets with Porous Structure and Their Non‐Enzymatic Glucose Sensing Applications

Cited by 17 publications

References 45 publications

Metal oxide-based composite for non-enzymatic glucose sensors

Metal oxide-based composite for non-enzymatic glucose sensors

Facile Synthesis of Pt-CuO Nanocomposite Films for Non-Enzymatic Glucose Sensor Application

Flexible Nonenzymatic Glucose Sensing with One‐Step Laser‐Fabricated Cu2O/Cu Porous Structure

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Flexible Nonenzymatic Glucose Sensing with One‐Step Laser‐Fabricated Cu₂O/Cu Porous Structure