Synthesis of Novel Derivatives of Imidazo[2,1-c][1,2,4]Triazine from Biologically Active 4-Arylidene-2-Hydrazino-1-Phenyl-1H-Imidazol-5(4H)-Ones and Evaluation of their Antimicrobial Activity

Abstract

Infectious microbial diseases cause worldwide problems, because microbes have resisted prophylaxis longer than any other form of life. In recent decades problems of multidrugresistant microorganisms have reached an alarming level in many countries around the world. Resistance to antimicrobial agents such as β-lactam antibiotics, macrolides, quinolones and vancomycin by different species of bacteria cause increasingly important global problems. 1 The available antimicrobial agents originate from a limited number of sources and most of them have similar modes of activity. It is very important to explore additional sources of substances with potential antimicrobial activity, which could possibly have different modes of activity, or affect different sites in bacterial and fungal cells.