2017
DOI: 10.3906/kim-1604-13
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Synthesis of novel derivatives of chromenone bearing an $N$-carbamothioyl moiety as soybean 15-LOX inhibitors

Abstract: Novel derivatives of chromenone bearing an N -carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2 H -chromen-2-one.It was reacted with 1-fluoro-2(4)-nitrobenzene to obtain the corresponding nitrophenoxy-chromenone derivative. Reduction of the nitro group was achieved in the presence of Zn/NH 4 Cl and reaction of the latter compound with in situ prepared benzoyl isothiocyanate led to the formation of the… Show more

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“…The synthesis of APF was performed based on the procedure published by Setsukinai and cooworkers 39 . The APC probe was synthesized according to the procedure published by Kavani and cooworkers 60 . The detailed description of synthetic procedures can be found in the Supplementary Information.…”
Section: Methodsmentioning
confidence: 99%
“…The synthesis of APF was performed based on the procedure published by Setsukinai and cooworkers 39 . The APC probe was synthesized according to the procedure published by Kavani and cooworkers 60 . The detailed description of synthetic procedures can be found in the Supplementary Information.…”
Section: Methodsmentioning
confidence: 99%