Synthesis of Novel Hantzsch Dihydropyridine Derivatives

Abstract

A one-pot synthesis of novel Hantzsch dihydropyridine derivatives via a three-component cyclocondensation reaction of p-nitro acetoacetanilide, aromatic aldehyde and aqueous ammonia solution is presented. The protocol avoids the use of expensive catalyst, toxic solvent and chromatographic separation.

Introducing an Effective Nanocatalytic for the One-Pot Synthesis and Investigation of Biological Properties of Pyranopyrimidinone and Xanthene Derivatives

“…In continuation of our previous studies [31][32][33][34][35][36][37], our research team has tried to introduce a simple and effective method for the synthesis of pyrano [2,3d]pyrimidine and xanthen derivatives.…”

Synthesis of podands with dihydropyrimidine fragments based on polyethers with terminal acetoacetamide groups

“…Immobilization of PPA on the surface of nanosized TiO 2 -SiO 2 oxide was performed according to a published procedure. 15 (2E,2'E)-Diethyl 3,3'-(2,2'-oxybis(ethane-2,1-diyl)bis-(azandiyl))dibut-2-enoate (3a). I.…”

“…Catalysis with PPA allowed to increase the yields of reaction products 9a,b to 18 and 27%, respectively, but led to problems with product isolation from the reaction mixture. By analogy to published procedures, 15,16 where the active component (PPA) was immobilized on silicon dioxide surface, we obtained a solid acidic catalyst by using nanosized ТiO 2 -SiO 2 as a support for PPA. Indeed, the PPA-modified nanosized ТiO 2 -SiO 2 oxide enabled a more selective interaction of podands 5a,b with urea (7) and benzaldehyde (8), producing the target dihydropyrimidine derivatives 9a,b in 41 and 52% yields, respectively.…”

ChemInform Abstract: Magnetite and Metal‐Impregnated Magnetite Catalysts in Organic Synthesis: A Very Old Concept with New Promising Perspectives

“…The synthesis of imidazoles [42] (Scheme 5), as well as other heterocycles, [43] has also been described. The synthesis was ac-Scheme1.Fe 3 O 4 -catalyzedr eductiono fn itroarenes.…”