Synthesis of novel heterocyclic Quinolone compound for anti -tubercular activity

Abstract

In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. The need of study was only because of there are many drugs in market to treat infection but most of the drugs are showing resistance because of the same it is difficult to treat the infection. In this study we chosen quinolone nucleus for study and over it. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance. Methodology: The synthesis of Quinolone derivatives, starting from substituted aniline and ethyl acetoacetate, by conventional organic reaction and results of investigations of their anti-mycobacterial activity. Results: MICs of the synthesized compounds are compared with existing drugs Cytotoxicity. The substituted quinolones are synthesized by taking mixture of 7-substituted-2-(3-chloro-2-oxopropyl) quinolin-4(1H)-one and different secondary amines. Many compounds have shown promising activity while some were inactive. Conclusion: It was found that Compound A1, A3, B1, B3, have shown promising anti tubercular activity whereas compound A2, A4,B2,B4 were showing moderate anti tubercular activity against std. Streptomycin.

Synthesis Docking Studies, Characterization and Anti-tubercular Activity of Ofloxacin Containing Thiazolidinone Derivatives

“…Ofloxacin is a new second-generation fluoroquinolone structurally related to nalidixic acid. 1 Fluoroquinolones were used widely for the treatment of mild to moderate bacterial infections. But that has been replaced by more potent and less toxic fluoroquinolones and ofloxacin is used worldwide topically as eye and ear drops.…”